ArticleThe Journal of physiology2007
Characterization of flow and mixing regimes within the ileum of the brushtail possum using residence time distribution analysis with simultaneous spatio-temporal mapping.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine.Neurogastroenterology and motility · 2026Article
- Small Intestine on a Chip Demonstrates Physiologic Mucus Secretion in the Presence of Lacticaseibacillus rhamnosus Biofilm.Biotechnology and bioengineering · 2025Article
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- Enchained growth and cluster dislocation: A possible mechanism for microbiota homeostasis.PLoS computational biology · 2019Article
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- Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines.Journal of visualized experiments : JoVE · 2016Article
- A Multiphase Flow in the Antroduodenal Portion of the Gastrointestinal Tract: A Mathematical Model.Computational and mathematical methods in medicine · 2016Article
- A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Article
- Fluid mechanical consequences of pendular activity, segmentation and pyloric outflow in the proximal duodenum of the rat and the guinea pig.Journal of the Royal Society, Interface · 2013Article
- Effects of hydrogen sulphide on motility patterns in the rat colon.British journal of pharmacology · 2013Article
- Electrogenic Cl(-) secretion does not occur in the ileum of the Australian common brushtail possum, Trichosurus vulpecula, due to low levels of expression of the NaK2Cl cotransporter, NKCC1.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2009Article
- Physical characteristics of digesta and their influence on flow and mixing in the mammalian intestine: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Review
- High-definition spatiotemporal mapping of contractile activity in the isolated proximal colon of the rabbit.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
- Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the flow and mixing regimes in isolated segments of the terminal ileum of brushtail possums during spontaneous circumferential and longitudinal contractions under conditions that allowed backflow and compared them with those of inactive segments. Residence time distributions (RTDs) were determined by perfusion with two probes of different rheological properties to which an inert dye marker was added. Ileal segment volume and oscillatory flow during the period of RTD determination were derived from spatiotemporal maps. High viscosity guar gum solution generated RTDs characteristic of laminar flow in inactive ileal segments which confirmed that no slip was occurring at the mucosal layer. In active segments, motility and consequent oscillatory flow imparted significant additional axial dispersion to the flow patterns of both probes. Mixing occurred episodically during periods when intestinal volume was reduced and onflow was augmented by peristalsis, which may prevent the establishment of steady state conditions. Marker concentration rose more steeply when active ileal segments were being perfused with a probe of similar viscosity to normal digesta than with low viscosity Earle's/Hepes solution, each being subject to similar levels of oscillatory flow. This indicated that a coarser mixing regime prevailed and that absorption of nutrients from viscous digesta would rely to a greater degree on molecular diffusion.
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