ArticleProceedings of the National Academy of Sciences of the United States of America2007
Plant domestication, a unique opportunity to identify the genetic basis of adaptation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers.
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182 citing papers in PubMed.
- The Landscape of Long Non-Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phenotypic Variation and Classification of Melon Germplasm Resources Based on DUS Test Characteristics.Plants (Basel, Switzerland) · 2026Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Assembly of Silphium interspecific hybrid genomes opens the genus to phylogenomics, ecogenomics, and molecular breeding.Nature communications · 2026Article
- Evolution of crop phenotypic spaces through domestication.The New phytologist · 2026Article
- Identification of Genetic Variation Associated With Heat Tolerance in Cowpea (Vigna unguiculata L. Walp.).Molecular ecology · 2026Article
- Genome-wide detection of selection signatures in roses.BMC plant biology · 2026Article
- Population structure and domestication history of the Javan banteng.Current biology : CB · 2026Article
- Maize leaf endosphere microbiome was affected by domestication and shows patterns consistent with microbial dysbiosis.Frontiers in microbiomes · 2026Article
- Reconstructing the evolutionary history of herbaceous crops through trait-based ecology.American journal of botany · 2025Review
- Evolutionary histories of functional mutations during the domestication and spread ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Convergent domestication of bitter apples and pears by selecting mutations of MYB transcription factors to reduce proanthocyanidin levels.Molecular horticulture · 2025Article
- Urban Life Shapes Genetic Diversity in the Green Anole, Anolis carolinensis.Molecular ecology · 2025Article
- A trans-species cytoplasmic polymorphism is associated with seed shape and aridity across multiple species of sunflowers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- In silico prediction of variant effects: promises and limitations for precision plant breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Review
- An ancient origin of the naked grains of maize.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative transcriptome analysis reveals candidate gene for flowering time QTL HvHeading in barley.BMC plant biology · 2025Article
- Insights into the genomic divergence of maize heterotic groups in China.Journal of integrative plant biology · 2025Article
- Oryza genome evolution through a tetraploid lens.Nature genetics · 2025Article
122 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
Despite the fundamental role of plant domestication in human history and the critical importance of a relatively small number of crop plants to modern societies, we still know little about adaptation under domestication. Here we focus on efforts to identify the genes responsible for adaptation to domestication. We start from a historical perspective, arguing that Darwin's conceptualization of domestication and unconscious selection provides valuable insight into the evolutionary history of crops and also provides a framework to evaluate modern methods used to decipher the genetic mechanisms underlying phenotypic change. We then review these methods, framing the discussion in terms of the phenotype-genotype hierarchy. Top-down approaches, such as quantitative trait locus and linkage disequilibrium mapping, start with a phenotype of interest and use genetic analysis to identify candidate genes. Bottom-up approaches, alternatively, use population genetic analyses to identify potentially adaptive genes and then rely on standard bioinformatics and reverse genetic tools to connect selected genes to a phenotype. We discuss the successes, advantages, and challenges of each, but we conclude that bottom-up approaches to understanding domestication as an adaptive process hold greater promise both for the study of adaptation and as a means to identify genes that contribute to agronomically important traits.
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