ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Thalamic Activity Regulates Interneuron Density in the Developing Visual Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Article
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Article
- Neuromodulatory control of inhibitory network arborization in the developing postnatal neocortex.Science advances · 2022Article
- Developmental and activity-dependent modulation of coupling distance between release site and CaFrontiers in cellular neuroscience · 2022Review
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders.Frontiers in neuroscience · 2022Review
- Review
- Neuronal Activity Patterns Regulate Brain-Derived Neurotrophic Factor Expression in Cortical CellsFrontiers in neuroscience · 2021Article
- Axon growth and synaptic function: A balancing act for axonal regeneration and neuronal circuit formation in CNS trauma and disease.Developmental neurobiology · 2020Review
- MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size.Nature communications · 2018Article
- Development of the Thalamocortical Interactions: Past, Present and Future.Neuroscience · 2018Review
- Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures.Journal of visualized experiments : JoVE · 2018Article
- Nucleocytoplasmic Shuttling of Histone Deacetylase 9 Controls Activity-Dependent Thalamocortical Axon Branching.Scientific reports · 2017Article
- Quantitative Analysis of Axonal Branch Dynamics in the Developing Nervous System.PLoS computational biology · 2016Article
- DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity.EMBO reports · 2015Article
- Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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4 authors.
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Abstract
Target and activity-dependent mechanisms of axonal branching were studied in the thalamocortical (TC) projection using organotypic cocultures of the thalamus and cortex. TC axons were labeled with enhanced yellow fluorescent protein (EYFP) by a single-cell electroporation method and observed over time by confocal microscopy. Changes in the firing activity of cocultures grown on multielectrode dishes were also monitored over time. EYFP-labeled TC axons exhibited more branch formation in and around layer 4 of the cortical explant during the second week in vitro, when spontaneous firing activity increased in both thalamic and cortical cells. Time-lapse imaging further demonstrated that branching patterns were generated dynamically by addition and elimination with a bias toward branch accumulation in the target layer. To examine the relationship between neural activity and TC branch formation, the dynamics of axonal branching was analyzed under various pharmacological treatments. Chronic blockade of firing or synaptic activity reduced the remodeling process, in particular, branch addition in the target layer. However, extension of branches was not affected by this treatment. Together, these findings suggest that neural activity can modify the molecular mechanisms that regulate lamina-specific TC axon branching.
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