ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Rhythmic episodes of subthreshold membrane potential oscillations in the rat inferior olive nuclei in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 96 citations in OpenAlex.
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Representations of Subsecond Duration-Based Timing by Complex Spike Synchrony in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Somatosensory Induced Cerebellar Responses to Peripheral Nerve Stimulation: A Time and Time-Frequency EEG Study.Brain sciences · 2026Article
- Control of action potential afterdepolarizations in the inferior olive by inactivating A-type currents through KThe Journal of physiology · 2025Article
- Wavenumber-dependent transmission of subthreshold waves on electrical synapses network model ofeLife · 2025Article
- Article
- Time and tide of cerebellar synchrony.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability.Biological cybernetics · 2022Review
- Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive NetworkFrontiers in cellular neuroscience · 2022Article
- Progerin-Induced Transcriptional Changes in Huntington's Disease Human Pluripotent Stem Cell-Derived Neurons.Molecular neurobiology · 2020Article
- Article
- Imaging Subthreshold Voltage Oscillation With Cellular Resolution in the Inferior OliveFrontiers in cellular neuroscience · 2020Article
- Role of cerebellar GABAergic dysfunctions in the origins of essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Complex Spike Wars: a New Hope.Cerebellum (London, England) · 2018Review
- In vivo analysis of synaptic activity in cerebellar nuclei neurons unravels the efficacy of excitatory inputs.The Journal of physiology · 2017Article
- The shaping of intrinsic membrane potential oscillations: positive/negative feedback, ionic resonance/amplification, nonlinearities and time scales.Journal of computational neuroscience · 2017Article
- Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition.Nature communications · 2017Article
- Oscillatory integration windows in neurons.Nature communications · 2016Article
- Electrical Coupling and Synchronized Subthreshold Oscillations in the Inferior Olive of the Rhesus Macaque.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro studies of inferior olive neurons demonstrate that they are intrinsically active, generating periodic spatiotemporal patterns. These self-generated patterns of activity extend the role of olivary neurons beyond that of a deliverer of teaching or error signals. However, autorhythmicity or patterned activity of complex spikes in the cerebellar cortex was observed in only a few studies. This discrepancy between the self-generated rhythmicity in the inferior olive observed in vitro and the sporadic reports on rhythmicity of complex spikes can be reconciled by recording intracellularly from inferior olive neurons in situ. To this end, we recorded intracellularly from olivary neurons of anesthetized rats. We demonstrate that, in vivo, olivary neurons show both slow and fast rhythmic processes. The slow process (0.2-2 Hz) is expressed as rhythmic transitions from quiescent periods to periods of fast rhythm, manifested as subthreshold oscillations of 6-12 Hz. Spikes, if they occur, are locked to the depolarized phase of these subthreshold oscillations and, therefore, hold and transfer rhythmic information. The transient nature of these oscillatory epochs accounts for the difficulties to uncover them by prolonged recordings of complex spikes activity in the cerebellar cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.