ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Synaptic Ca2+ in darkness is lower in rods than cones, causing slower tonic release of vesicles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Transmission at rod and cone ribbon synapses in the retina.Pflugers Archiv : European journal of physiology · 2021Review
- Functional compartmentalization of photoreceptor neurons.Pflugers Archiv : European journal of physiology · 2021Review
- Article
- Resting and stimulated mouse rod photoreceptors show distinct patterns of vesicle release at ribbon synapses.The Journal of general physiology · 2020Article
- Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics.eLife · 2020Article
- Kiss-and-Run Is a Significant Contributor to Synaptic Exocytosis and Endocytosis in Photoreceptors.Frontiers in cellular neuroscience · 2017Article
- Parallel Computations in Insect and Mammalian Visual Motion Processing.Current biology : CB · 2016Review
- Article
- Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors.The Journal of general physiology · 2014Article
- Rapid kinetics of endocytosis at rod photoreceptor synapses depends upon endocytic load and calcium.Visual neuroscience · 2014Article
- Presynaptic [Ca(2+)] and GCAPs: aspects on the structure and function of photoreceptor ribbon synapses.Frontiers in molecular neuroscience · 2014Review
- Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors.Stem cells (Dayton, Ohio) · 2013Article
- Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Light-driven calcium signals in mouse cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.Frontiers in molecular neuroscience · 2012Article
- Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.Journal of neurophysiology · 2011Article
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
- A positive feedback synapse from retinal horizontal cells to cone photoreceptors.PLoS biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Rod and cone photoreceptors use specialized biochemistry to generate light responses that differ in their sensitivity and kinetics. However, it is unclear whether there are also synaptic differences that affect the transmission of visual information. Here, we report that in the dark, rods tonically release synaptic vesicles at a much slower rate than cones, as measured by the release of the fluorescent vesicle indicator FM1-43. To determine whether slower release results from a lower Ca2+ sensitivity or a lower dark concentration of Ca2+, we imaged fluorescent indicators of synaptic vesicle cycling and intraterminal Ca2+. We report that the Ca2+ sensitivity of release is indistinguishable in rods and cones, consistent with their possessing similar release machinery. However, the dark intraterminal Ca2+ concentration is lower in rods than in cones, as determined by two-photon Ca2+ imaging. The lower level of dark Ca2+ ensures that rods encode intensity with a slower vesicle release rate that is better matched to the lower information content of dim light.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.