ArticleJournal of virology2007
Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Age-Stratified Treg Responses During Viral Infections of the Central Nervous System: A Literature Review.Journal of medical virology · 2025Review
- Lassa virus persistence with high viral titers following experimental infection in its natural reservoir host, Mastomys natalensis.Nature communications · 2024Article
- T cells in the brain enhance neonatal mortality during peripheral LCMV infection.PLoS pathogens · 2021Article
- A NewFrontiers in immunology · 2018Article
- Differential mucosal IL-10-induced immunoregulation of innate immune responses occurs in influenza infected infants/toddlers and adults.Immunology and cell biology · 2017Article
- Early life vaccination: Generation of adult-quality memory CD8+ T cells in infant mice using non-replicating adenoviral vectors.Scientific reports · 2016Article
- Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.Nature immunology · 2016Article
- Rapid CD8Frontiers in pediatrics · 2016Article
- Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.PloS one · 2013Article
- The impact of differential antiviral immunity in children and adults.Nature reviews. Immunology · 2012Review
- Selective accumulation of Th2-skewing immature erythroid cells in developing neonatal mouse spleen.International journal of biological sciences · 2012Article
- Long-lasting protective antiviral immunity induced by passive immunotherapies requires both neutralizing and effector functions of the administered monoclonal antibody.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral infections in human infants frequently follow a protracted course, with higher viral loads and delayed viral clearance compared to viral infections in older children. To identify the mechanisms responsible for this protracted pattern of infection, we developed an infant infection murine model using the well-characterized lymphocytic choriomeningitis virus (LCMV) WE strain in 2-week-old BALB/c mice. In contrast to adult mice, in which viral clearance occurred as expected 8 days after infection, LCMV titers persisted for several weeks after infection of infant mice. LCMV-specific effector CD8(+) T cells were elicited in infant mice and fully functional on day 7 but rapidly waned and could not be recovered from day 12 onwards. We show here that this results from the failure of LCMV-specific CD8(+) T cells to expand and the absence of protective LCMV-specific memory CD8(+) T cells. Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.