Evidence map›Paper›PMID 17494057›Full record

ReviewEpidemiologic reviews2007

Biomarkers of obesity and subsequent cardiovascular events.

Salma Musaad, Erin N Haynes

Registry-linked trialAbstract readReview
In one paragraph

Review in Epidemiologic reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04988893 (Quality of Recovery Scores in Parturients With Obesity), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04988893 completednot on this mapstarted 2021, after this paper: background citation

Quality of Recovery Scores in Parturients With Obesity: A Prospective Observational Cohort Study

TypeobservationalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2021 to 2023Enrolled140ConditionsQuality of Recovery, Post Operative Pain
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Review
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  8. Review
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  17. Neutrophil/lymphocyte ratio in obese adolescents.Northern clinics of Istanbul · 2015
    Article
  18. Article
  19. Article
  20. Cardiac autonomic dysfunction in obese normotensive children and adolescents.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Salma MusaadDivision of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA. musaaadsm@email.uc.edu
Erin N Haynes

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)T32ES010957 · NIEHS · UNIVERSITY OF CINCINNATI · PI Kelly J Brunst · 2001 to 2026
$11.1M
NIEHS NIH HHS 5T32 ES 10957NIEHS NIH HHS P30 ES006096NIEHS NIH HHS T32 ES010957
6 · The paper itself

Abstract

Obesity is a major risk factor for cardiovascular diseases, but the mechanisms for increased cardiovascular risk in obesity are still unclear. Inflammation and increased oxidative stress are two potential mechanisms proposed to play a major role in the morbidity associated with obesity. Studies that investigate these mechanisms rely on biomarkers, but validated biomarkers for obesity-related cardiovascular outcomes are lacking. By finding optimal biomarkers, diagnostic criteria for cardiovascular diseases can be refined in the obese beyond "traditional" risk factors to identify early pathologic processes. The objective of this review is to identify potential early biomarkers resulting from obesity and associated with cardiovascular disease. Studies were initially identified through the search engine PubMed by using the keywords "obesity" and "biomarker." Subsequently, combinations of the keywords "obesity," "biomarker," "cardiovascular risk," "adipose tissue," "adipokine," "adipocytokine," and "oxidative stress" were used. The SOURCE database and Online Mendelian Inheritance in Man (OMIM) were used to obtain more information on the biomarkers. Results of the searches yielded a large number of potential biomarkers that occur in obesity and which either correlate with traditional cardiovascular risk factors or predict subsequent cardiovascular events. Several biomarkers are promising regarding their biologic properties, but they require further validation in humans.

Indexed as

BiomarkersCardiovascular DiseasesHumansInflammationObesityOxidative StressRisk FactorsBiomarkers

Identifiers

PMID17494057
PMCPMC4682894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.