ArticleArchives of biochemistry and biophysics2007
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
Article in Archives of biochemistry and biophysics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- The Biosynthesis and Metabolism of theFrontiers in molecular biosciences · 2021Review
- Structural and Chemical Biology of the Interaction of Cyclooxygenase with Substrates and Non-Steroidal Anti-Inflammatory Drugs.Chemical reviews · 2020Review
- Review
- Novel COX-2 products ofJournal of lipid research · 2019Article
- Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Review
- Endocannabinoids, related compounds and their metabolic routes.Molecules (Basel, Switzerland) · 2014Review
- ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations.Journal of the American Chemical Society · 2014Article
- The cannabinoid acids, analogs and endogenous counterparts.Bioorganic & medicinal chemistry · 2014Review
- The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.The Journal of biological chemistry · 2014Article
- Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases.Lipids · 2012Article
- Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways.Chemical reviews · 2011Review
- Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality.Life sciences · 2010Review
- Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase.Biochemistry · 2009Article
- T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Biosynthesis, degradation and pharmacological importance of the fatty acid amides.Drug discovery today · 2008Review
- Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.Biochemistry · 2008Article
- The complications of promiscuity: endocannabinoid action and metabolism.British journal of pharmacology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The lipoamino acids and endovanilloids have multiple roles in nociception, pain, and inflammation, yet their biological reactivity has not been fully characterized. Cyclooxygenases (COXs) and lipoxygenases (LOs) oxygenate polyunsaturated fatty acids to generate signaling molecules. The ability of COXs and LOs to oxygenate arachidonyl-derived lipoamino acids and vanilloids was investigated. COX-1 and COX-2 were able to minimally metabolize many of these species. However, the lipoamino acids were efficiently oxygenated by 12S- and 15S-LOs. The kinetics and products of oxygenation by LOs were characterized. Whereas 15S-LOs retained positional specificity of oxygenation with these novel substrates, platelet-type 12S-LO acted as a 12/15-LO. Fatty acid oxygenases may play an important role in the metabolic inactivation of lipoamino acids or vanilloids or may convert them to bioactive derivatives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.