ReviewCritical care (London, England)2007
Bench-to-bedside review: pulmonary-renal syndromes--an update for the intensivist.
Review in Critical care (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 85 citations in OpenAlex.
- Immunological overlap stratification in anti-GBM disease: prognostic differences and serological correlations-a single-center retrospective cohort study.Frontiers in immunology · 2026Article
- Article
- Massive hemoptysis with end stage renal disease (ESRD): An initial symptom of rare disease.Clinical case reports · 2024Article
- Article
- Pulmonary Manifestations at Different Stages in the Chronic Kidney Disease: An Observational Study.Cureus · 2023Article
- Diffuse alveolar hemorrhage in children with interstitial lung disease: Determine etiologies!Pediatric pulmonology · 2023Article
- Pulmonary renal syndrome: a clinical review.Breathe (Sheffield, England) · 2022Review
- Pulmonary-Renal Syndrome: A Real-World Experience From a Tertiary Care Pulmonary Center in North India.Cureus · 2022Article
- A challenging case of pneumo-renal syndrome (Nephrology Zebras).Journal of nephrology · 2021Article
- [A rare and severe complication related to acenocoumarol therapy: intra-alveolar bleeding].The Pan African medical journal · 2019Article
- Article
- Clinical mimics: an emergency medicine focused review of pneumonia mimics.Internal and emergency medicine · 2018Review
- Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report).Open access Macedonian journal of medical sciences · 2016Article
- Concurrent pulmonary hemorrhage and deep vein thrombosis in a child with ANCA-associated vasculitis: case report and review of literature.Pediatric rheumatology online journal · 2015Review
- Pulmonary-renal syndromes: Experience from an Indian Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- [Acute respiratory and renal failure in a 20-year-old man].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2015Article
- Acute kidney injury with hypoxic respiratory failure.BMJ case reports · 2014Article
- AP-VAS 2012 case report: anti-glomerular basement membrane disease with high titer of myeloperoxidase anti-neutrophil cytoplasmic antibody-an autopsy case report.CEN case reports · 2013Article
- Pulmonary-Renal Syndrome with Negative ANCAs and Anti-GBM Antibody.Case reports in nephrology · 2013Article
- Update on diffuse alveolar hemorrhage and pulmonary vasculitis.Immunology and allergy clinics of North America · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term Pulmonary-renal syndrome refers to the combination of diffuse alveolar haemorrhage and rapidly progressive glomerulonephritis. A variety of mechanisms such as those involving antiglomerular basement membrane antibodies, antineutrophil cytoplasm antibodies or immunocomplexes and thrombotic microangiopathy are implicated in the pathogenesis of this syndrome. The underlying pulmonary pathology is small-vessel vasculitis involving arterioles, venules and, frequently, alveolar capillaries. The underlying renal pathology is a form of focal proliferative glomerulonephritis. Immunofluorescence helps to distinguish between antiglomerular basement membrane disease (linear deposition of IgG), lupus and postinfectious glomerulonephritis (granular deposition of immunoglobulin and complement) and necrotizing vasculitis (pauci-immune glomerulonephritis). Patients may present with severe respiratory and/or renal failure and require admission to the intensive care unit. Since the syndrome is characterized by a fulminant course if left untreated, early diagnosis, exclusion of infection, close monitoring of the patient and timely initiation of treatment are crucial for the patient's outcome. Treatment consists of corticosteroids in high doses, and cytotoxic agents coupled with plasma exchange in certain cases. Renal transplantation is the only alternative in end-stage renal disease. Newer immunomodulatory agents such as those causing TNF blockade, B-cell depletion and mycophenolate mofetil could be used in patients with refractory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.