ArticleMolecular microbiology2007
Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.
Article in Molecular microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Activation of bacterial transcription by distortion of promoter base pairing.Nucleic acids research · 2026Article
- Rok from B. subtilis: Bridging genome structure and transcription regulation.Molecular microbiology · 2025Review
- The B. subtilis Rok protein is an atypical H-NS-like protein irresponsive to physico-chemical cues.Nucleic acids research · 2022Article
- MgrA Activates Staphylococcal Capsule via SigA-Dependent Promoter.Journal of bacteriology · 2020Article
- Article
- DNA-Binding and Transcription Activation by Unphosphorylated Response Regulator AgrR FromFrontiers in microbiology · 2020Article
- The architects of bacterial DNA bridges: a structurally and functionally conserved family of proteins.Open biology · 2019Article
- How bacterial xenogeneic silencer rok distinguishes foreign from self DNA in its resident genome.Nucleic acids research · 2018Article
- Viscous drag on the flagellum activates Bacillus subtilis entry into the K-state.Molecular microbiology · 2017Article
- Intermediate Levels of Bacillus subtilis CodY Activity Are Required for Derepression of the Branched-Chain Amino Acid Permease, BraB.PLoS genetics · 2015Article
- Interactive regulation by the Bacillus subtilis global regulators CodY and ScoC.Molecular microbiology · 2015Article
- A Novel Feedback Loop That Controls Bimodal Expression of Genetic Competence.PLoS genetics · 2015Article
- Construction of a Super-Competent Bacillus subtilis 168 Using the P mtlA -comKS Inducible Cassette.Frontiers in microbiology · 2015Article
- The ResD response regulator, through functional interaction with NsrR and fur, plays three distinct roles in Bacillus subtilis transcriptional control.Journal of bacteriology · 2014Article
- Spo0A positively regulates epr expression by negating the repressive effect of co-repressors, SinR and ScoC, in Bacillus subtilis.Journal of biosciences · 2013Article
- Agent-based modeling of competence phenotype switching in Bacillus subtilis.Theoretical biology & medical modelling · 2013Article
- Article
- Global transcriptional control by NsrR in Bacillus subtilis.Journal of bacteriology · 2012Article
- Spo0A~P imposes a temporal gate for the bimodal expression of competence in Bacillus subtilis.PLoS genetics · 2012Article
- Indirect repression by Bacillus subtilis CodY via displacement of the activator of the proline utilization operon.Journal of molecular biology · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Competence for genetic transformation in the bacterium Bacillus subtilis is a bistable differentiation process governed by the minor groove DNA binding protein ComK. No detectable comK transcription occurs in the absence of an intact comK gene, indicating that ComK has auto-activating properties. ComK auto-stimulation, which is dependent on ComK binding to the comK promoter, is a critical step in competence development, ensuring quick and high-level expression of the late-competence genes. Auto-stimulation is also essential for the bistable expression pattern of competence. Here, we demonstrate that ComK acts as an activator at its own promoter by antagonizing the action of two repressors, Rok and CodY. Importantly, antirepression occurs without preventing binding of the repressing proteins, suggesting that ComK and the repressors might bind at distinct surfaces of the DNA helix. DegU, a DNA binding protein known to increase the affinity of ComK for its own promoter, potentiates the antirepression activity of ComK. We postulate that antirepression is primarily achieved through modulation of DNA topology. Although to our knowledge ComK is the only DNA binding protein shown to act in this novel fashion, other minor groove binding proteins may act similarly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.