ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Genetic architecture of fear conditioning in chromosome substitution strains: relationship to measures of innate (unlearned) anxiety-like behavior.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of sex-specific genome-wide association studies.Genetic epidemiology · 2010Pooled it
- Substrain-specific behavioral variation in female C57BL/6 and C57BL/10 mice.Frontiers in behavioral neuroscience · 2026Article
- Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior.Cell genomics · 2024Article
- Anxiety is correlated with running in adolescent female mice undergoing activity-based anorexia.Behavioral neuroscience · 2015Article
- High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice.Genetics · 2014Article
- A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs.Genes, brain, and behavior · 2013Article
- Genome-wide association for fear conditioning in an advanced intercross mouse line.Behavior genetics · 2012Article
- Article
- The clinical implications of mouse models of enhanced anxiety.Future neurology · 2011Article
- The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains.Behavior genetics · 2010Article
- Genomic survey of prepulse inhibition in mouse chromosome substitution strains.Genes, brain, and behavior · 2009Article
- Genetic relationship between anxiety-related and fear-related behaviors in BXD recombinant inbred mice.Behavioural pharmacology · 2009Article
- Sex-specific genetic architecture of human disease.Nature reviews. Genetics · 2008Review
- Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms.Genes, brain, and behavior · 2008Article
- Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysis.Behavior genetics · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We measured fear conditioning (FC) in a panel of chromosome substitution strains (CSS) created using the C57BL/6J (B6) and A/J (AJ) inbred strains. Mice were trained to associate a specific context and tone with a foot shock. FC was measured by observing freezing behavior during re-exposure to the context and tone. Freezing to context was more than twofold greater in the AJ strain relative to the B6 strain. Among the CSS we identified four strains with higher (CSS-6, -10, -11, and -18) and two strains with lower (CSS-7 and -14) freezing to context. CSS-10 and -18 also showed higher freezing to tone, while CSS-12 showed less freezing to tone. CSS-1 has been implicated in open-field (OF) and light-dark box (LDB); we observed significant activity differences prior to training but no differences in FC. Chromosomes 6 and 10 have been associated with differences in anxiety-like behaviors, suggesting the existence of pleiotropic alleles that influence both learned and innate fear. By utilizing a genetic reference population, we have identified chromosomes that pleiotropically influence multiple phenotypes hypothesized to reflect a common ethologic construct that has been termed emotionality. The CSS provide a straightforward means of isolating the underlying genetic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.