ArticlePflugers Archiv : European journal of physiology2007
Redox reaction modulates transient and persistent sodium current during hypoxia in guinea pig ventricular myocytes.
Article in Pflugers Archiv : European journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- Role of NADPH oxidase 2-derived reactive oxygen species in cardiac electrophysiological disorders.Channels (Austin, Tex.) · 2026Review
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- Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?Pharmaceuticals (Basel, Switzerland) · 2022Review
- Late Sodium Current Inhibitors as Potential Antiarrhythmic Agents.Frontiers in pharmacology · 2020Review
- Tolterodine reduces veratridine-augmented late IActa pharmacologica Sinica · 2016Article
- Cardiac melanocytes influence atrial reactive oxygen species involved with electrical and structural remodeling in mice.Physiological reports · 2015Article
- Redox control of cardiac excitability.Antioxidants & redox signaling · 2013Review
- Article
- Left-to-right ventricular differences in I(KATP) underlie epicardial repolarization gradient during global ischemia.Heart rhythm · 2011Article
- Hypoxia. 4. Hypoxia and ion channel function.American journal of physiology. Cell physiology · 2011Review
- Novel insights into the cellular basis of atrial fibrillation.Expert review of cardiovascular therapy · 2010Article
- Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia.Circulation research · 2009Article
- The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide.British journal of pharmacology · 2009Article
- Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.The Journal of clinical investigation · 2009Article
- Modulation of K(ATP) currents in rat ventricular myocytes by hypoxia and a redox reaction.Acta pharmacologica Sinica · 2009Article
- Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts.American journal of physiology. Cell physiology · 2009Article
- The cardiac persistent sodium current: an appealing therapeutic target?British journal of pharmacology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-cell and cell-attached patch clamp techniques were applied on isolated guinea pig ventricular myocytes to study the possible regulatory mechanisms of redox agent on persistent and transient sodium current related to hypoxia. The results showed that hypoxia for 15 min increased persistent sodium current (I (Na.P)) and decreased transient sodium current (I (Na.T)) at the same time, while 1 mmol/l of reduced glutathione (GSH) could reverse the increased I (Na.P) and the decreased I (Na.T) simultaneously. Both persistent and transient sodium channel activities could be reversed concurrently again by application of 1 mmol/l oxidized glutathione (GSSG). Hypoxia for 15 min decreased the action potential amplitude (APA) and shortened action potential duration at 90% repolarization (APD(90)) of ventricular papillary cells simultaneously, while 1 mmol/GSH could reverse the decreased APA and the shortened APD(90) at the same time; 1 mmol/l GSSG strengthened the decrease of APA induced by hypoxia and attenuated the decurtation of APD(90) induced by hypoxia compared with pure hypoxia. The correlation between I (Na.P) and I (Na.T) and the effects of GSH and GSSG on them suggested that during hypoxia, redox regulation played a tremendous part in sodium channel activity and that I (Na.P) and I (Na.T) might be charged by the same channel with different gating modes in guinea pig ventricular myocytes. Judging from their alterations during hypoxia and exposure to GSH and GSSG, we speculated that an interconversion might exist between I (Na.P) and I (Na.T). That was when one of them was increased, the other was decreased, and vice versa.
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