ArticleThe review of diabetic studies : RDS2004
Existence of islet regenerating factors within the pancreas.
Article in The review of diabetic studies : RDS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Ashwagandha (Iranian journal of basic medical sciences · 2026Review
- Investigation of the Effects of Curcumin on GLP1-R in Liver Tissue of Diabetic Rats.Archives of Razi Institute · 2024Article
- Examination of the immunohistochemical localization and gene expression by RT-PCR of the oxytocin receptor in diabetic and non-diabetic mouse testis.Iranian journal of basic medical sciences · 2018Article
- GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum.Journal of veterinary research · 2018Article
- Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function.BMJ open diabetes research & care · 2015Article
- Article
- Oreocnide integrifolia Flavonoids Augment Reprogramming for Islet Neogenesis and β-Cell Regeneration in Pancreatectomized BALB/c Mice.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis: In Vivo Studies in Murine Diabetes Model.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2010Article
- Approaches towards endogenous pancreatic regeneration.The review of diabetic studies : RDS · 2005Article
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2 authors.
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Abstract
Reduction in the functional mass of beta-cells is a common denominator in most forms of diabetes. Since the replicative potential of beta-cells is limited, the search for factors that trigger islet neogenesis becomes imperative. Here we tested the hypothesis that regenerating factors for the pancreas are either secreted by or present within the pancreatic milieu itself. For this purpose, we intraperitoneally injected pancreatic cell culture supernatant (PCCS), from normal pancreas, into streptozotocin (STZ)-induced diabetic mice for 15 consecutive days. The PCCS-treated mice showed sustained reversal in 77.77% of experimental diabetic mice as evidenced by restoration of normoglycemia, increase in serum insulin levels and occurrence of neo islets in histopathological studies during a two month follow up, as opposed to the control diabetic mice which remained hyperglycemic throughout. In order to examine the potential of PCCS to bring about the regeneration of islets, we treated intra-islet precursor cells with PCCS in vitro, which led to the neogenesis of islets as evidenced by dithiozone and insulin immunostaining. These findings substantiate our hypothesis and make the search for regenerative factors converge towards the pancreas and its immediate surroundings. Such regenerative approaches, in combination with other therapeutic strategies to promote islet neogenesis may, in future, provide a cure and/or better means for the control and management of diabetes.
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