ArticleThe EMBO journal2007
G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
35 citing papers in PubMed, 72 citations in OpenAlex.
- Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury.PLoS genetics · 2021Article
- Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma.Cancers · 2021Article
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Activation of β- and α2-adrenergic receptors stimulate tubulin polymerization and promote the association of Gβγ with microtubules in cultured NIH3T3 cells.Biochemical and biophysical research communications · 2018Article
- Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3.Scientific reports · 2018Article
- Tctex-1 controls ciliary resorption by regulating branched actin polymerization and endocytosis.EMBO reports · 2017Article
- β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis.Investigative ophthalmology & visual science · 2017Article
- Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB.The Journal of biological chemistry · 2016Article
- SARA regulates neuronal migration during neocortical development through L1 trafficking.Development (Cambridge, England) · 2016Article
- Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity.Oncotarget · 2016Article
- Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.Molecular & cellular proteomics : MCP · 2015Article
- Chlamydia trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 (Tctex1).Biochemical and biophysical research communications · 2015Article
- Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead.Neurotoxicology · 2015Article
- Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction.BMC neuroscience · 2014Article
- Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.Neurogenetics · 2014Article
- Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad.Molecular pharmacology · 2014Review
- IGF-1 activates a cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression.Developmental cell · 2013Article
- Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.Molecular biology of the cell · 2013Article
- Microtubule-organizing center formation at telomeres induces meiotic telomere clustering.The Journal of cell biology · 2013Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Tctex-1, a light-chain component of the cytoplasmic dynein motor complex, can function independently of dynein to regulate multiple steps in neuronal development. However, how dynein-associated and dynein-free pools of Tctex-1 are maintained in the cell is not known. Tctex-1 was recently identified as a Gbetagamma-binding protein and shown to be identical to the receptor-independent activator of G protein signaling AGS2. We propose a novel role for the interaction of Gbetagamma with Tctex-1 in neurite outgrowth. Ectopic expression of either Tctex-1 or Gbetagamma promotes neurite outgrowth whereas interfering with their function inhibits neuritogenesis. Using embryonic mouse brain extracts, we demonstrate an endogenous Gbetagamma-Tctex-1 complex and show that Gbetagamma co-segregates with dynein-free fractions of Tctex-1. Furthermore, Gbeta competes with the dynein intermediate chain for binding to Tctex-1, regulating assembly of Tctex-1 into the dynein motor complex. We propose that Tctex-1 is a novel effector of Gbetagamma, and that Gbetagamma-Tctex-1 complex plays a key role in the dynein-independent function of Tctex-1 in regulating neurite outgrowth in primary hippocampal neurons, most likely by modulating actin and microtubule dynamics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.