ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2007
Diabetes slows the recovery from urinary incontinence due to simulated childbirth in female rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluation of the relationship between the pelvic floor muscles and insulin resistance.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Article
- Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach.International urogynecology journal · 2014Article
- Animal models of stress urinary incontinence.Handbook of experimental pharmacology · 2011Review
- Pudendal nerve injury reduces urethral outlet resistance in diabetic rats.American journal of physiology. Renal physiology · 2010Article
- Temporal morphological and functional impact of complete urinary diversion on the bladder: a model of bladder disuse in rats.The Journal of urology · 2010Article
- Postpartum stress urinary incontinence: lessons from animal models.Expert review of obstetrics & gynecology · 2010Article
- Animal models of female stress urinary incontinence.The Journal of urology · 2008Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
This study was done to test the hypothesis that simulated vaginal birth by vaginal distension (VD) causes more severe urinary incontinence and slower recovery in diabetic rats. After measuring baseline leak point pressure (LPP) in 16 diabetes mellitus (DM) and 16 age- and weight-matched control (Ct) female Sprague-Dawley rats, these animals underwent either VD or sham VD (sham). Four and ten days after the procedures, LPP and conscious cystometry were assessed. Tissues were then harvested and examined by light microscopy. LPP at baseline was equal among all four groups. Four days after VD, LPP in both VD groups dropped to significantly lower levels than in sham rats (P < 0.001). Moreover, LPP in the DM+VD group was significantly lower than in the Ct+VD group. At 10 days, LPP in the Ct+VD group had recovered to its baseline value, whereas the LPP in the DM+VD group remained significantly reduced. DM rats had larger bladder capacity and longer voiding intervals than Ct rats. Histological findings included more severe damage to the external sphincter striated musculature of the urethra in DM+VD group compared with Ct+VD. In conclusion, these findings suggest that DM causes increased severity and delayed functional recovery from the effects of simulated childbirth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.