ArticleBritish journal of haematology2007
Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein.
Article in British journal of haematology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Palmitoylation-dependent regulation of innate and adaptive immunity: molecular insights and translational opportunities.Cellular & molecular biology letters · 2026Review
- Regulation of Adaptive Immunity by Lipid Post-translational Modifications.Immune network · 2025Review
- Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150.Frontiers in immunology · 2024Review
- Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling.Blood advances · 2019Article
- Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study.Development and psychopathology · 2018Article
- Article
- Gene expression profile analysis identifies metastasis and chemoresistance-associated genes in epithelial ovarian carcinoma cells.Medical oncology (Northwood, London, England) · 2015Article
- A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks.Nature genetics · 2014Article
- Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics.Molecular & cellular proteomics : MCP · 2013Article
- Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.Nature communications · 2013Article
- Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A strategy for full interrogation of prognostic gene expression patterns: exploring the biology of diffuse large B cell lymphoma.PloS one · 2011Article
- Article
- Syk and pTyr'd: Signaling through the B cell antigen receptor.Biochimica et biophysica acta · 2009Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
GCET2 (Germinal centre B-cell expressed transcript 2; also named HGAL) is a newly cloned gene that has been shown to be a useful marker for germinal centre (GC) B cells and GC B-cell derived malignancies, including follicular lymphomas and germinal centre B cell-like diffuse large B-cell lymphomas (GCB-DLBCLs), and is a useful prognosticator for DLBCLs. We report here the biochemical and biological properties of GCET2, which may help to determine its role in the GC reaction. GCET2 is constitutively localised in the plasma membrane but is excluded from lipid rafts. GCET2 does not have a transmembrane domain, and its membrane localisation is mediated by myristoylation and palmitoylation. GCET2 has five conserved putative tyrosine phosphorylation sites, and it can be phosphorylated following pervanadate treatment in B cells. By serially mutating the five tyrosines, the third and fourth tyrosines were found to be essential for GCET2 phosphorylation. GCET2 was phosphorylated when co-transfected into COS7 cells with protein tyrosine kinases (PTKs) LYN, LCK or SYK, and therefore it could be a substrate of these kinases in B cells. The third tyrosine site ((107)YENV) of GCET2 is a consensus GRB2 binding site, and GCET2 was found to associate with GRB2 through the third tyrosine following phosphorylation. Our data suggests that GCET2 may be an adaptor protein in GC B cells that transduces signals from GC B-cell membrane to the cytosol via its association with GRB2.
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