ArticleJournal of neurophysiology2007
Ih without Kir in adult rat retinal ganglion cells.
Article in Journal of neurophysiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
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- Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.The Journal of physiology · 2014Article
- The effect of morphology upon electrophysiological responses of retinal ganglion cells: simulation results.Journal of computational neuroscience · 2014Article
- Article
- Ionic mechanisms underlying tonic and phasic firing behaviors in retinal ganglion cells: a model study.Channels (Austin, Tex.) · 2014Article
- Directional summation in non-direction selective retinal ganglion cells.PLoS computational biology · 2013Article
- Thy1 associates with the cation channel subunit HCN4 in adult rat retina.Investigative ophthalmology & visual science · 2012Article
- Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.The Journal of comparative neurology · 2011Article
- Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells.Neuron · 2011Article
- Article
- Muscarinic acetylcholine receptor localization and activation effects on ganglion response properties.Investigative ophthalmology & visual science · 2010Article
- Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Ectopic expression of multiple microbial rhodopsins restores ON and OFF light responses in retinas with photoreceptor degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium.Experimental eye research · 2008Article
- HCN4-like immunoreactivity in rat retinal ganglion cells.Visual neuroscienceArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Antisera directed against hyperpolarization-activated mixed-cation ("I(h)") and K(+) ("K(ir)") channels bind to some somata in the ganglion cell layer of rat and rabbit retina. Additionally, the termination of hyperpolarizing current injections can trigger spikes in some cat retinal ganglion cells, suggesting a rebound depolarization arising from activation of I(h). However, patch-clamp studies showed that rat ganglion cells lack inward rectification or present an inwardly rectifying K(+) current. We therefore tested whether hyperpolarization activates I(h) in dissociated, adult rat retinal ganglion cell somata. We report here that, although we found no inward rectification in some cells, and a K(ir)-like current in a few cells, hyperpolarization activated I(h) in roughly 75% of the cells we recorded from in voltage clamp. We show that this current is blocked by Cs(+) or ZD7288 and only slightly reduced by Ba(2+), that the current amplitude and reversal potential are sensitive to extracellular Na(+) and K(+), and that we found no evidence of K(ir) in cells presenting I(h). In current clamp, injecting hyperpolarizing current induced a slowly relaxing membrane hyperpolarization that rebounded to a few action potentials when the hyperpolarizing current was stopped; both the membrane potential relaxation and rebound spikes were blocked by ZD7288. These results provide the first measurement of I(h) in mammalian retinal ganglion cells and indicate that the ion channels of rat retinal ganglion cells may vary in ways not expected from previous voltage and current recordings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.