ArticlePostgraduate medical journal2007
Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia.
Article in Postgraduate medical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Evidence for association of the E23K variant of KCNJ11 gene with type 2 diabetes in Tunisian population: population-based study and meta-analysis.BioMed research international · 2014Pooled it
- Functional ADAM12 variants modulate proteolytic activity and influence metabolic traits.Scientific reports · 2026Article
- Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review.Metabolism open · 2024Review
- Review
- Whole Exome Sequencing Study in a Family with Type 2 Diabetes Mellitus.International journal of general medicine · 2021Article
- Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study.Scientific reports · 2019Article
- A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.Frontiers in endocrinology · 2019Article
- Prion-Like Protein Aggregates and Type 2 Diabetes.Cold Spring Harbor perspectives in medicine · 2017Review
- Designing an electronic personal health record for professional Iranian athletes.Asian journal of sports medicine · 2014Article
- Prevalence of insulin resistance in siblings of type 2 diabetics of north west punjabi population.Journal of clinical and diagnostic research : JCDR · 2014Article
- Article
- Presence of diabetes mellitus in the 'Dawoodi Bohra youth community' in Udaipur, Rajasthan.The Indian journal of medical research · 2014Article
- Familial Clustering of Type 2 Diabetes among Omanis.Oman medical journal · 2014Article
- Parental transmission of type 2 diabetes mellitus in a highly endogamous population.World journal of diabetes · 2013Article
- Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model.ISRN endocrinology · 2012Article
- Developmental origins of type 2 diabetes in aboriginal youth in Canada: it is more than diet and exercise.Journal of nutrition and metabolism · 2012Article
- Maternal effect and familial aggregation in a type 2 diabetic Moroccan population.Journal of community health · 2011Article
- Influence of socioeconomic lifestyle factors and genetic polymorphism on type 2 diabetes occurrences among Tunisian Arab and Berber groups of Djerba Island.Pharmacogenomics and personalized medicine · 2009Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the degree of familial aggregation of type 2 diabetes mellitus in Tunisia and to investigate transmission patterns of the disease and their relationships with patients' clinical profiles.
methodsFamily history of diabetes and clinical data were collected for 132 unrelated type 2 diabetic Tunisian patients. Diabetes status was recorded for first degree relatives (parents, siblings) and second degree relatives (aunts and uncles from both maternal and paternal sides). Information about family history of diabetes was gathered for a total of 1767 individuals.
resultsFamilial aggregation of type 2 diabetes was prominent and more important among first degree relatives than among second degree relatives (p = 0.01). Among studied subjects, 70% reported at least one relative with diabetes and 34% had at least one parent with diabetes. Diabetes was more frequent among mothers than fathers of probands (p = 0.03). This maternal effect extends to second degree relatives as diabetes was more common among maternal than paternal aunts and uncles (p = 0.01). There is no significant difference in clinical and metabolic profiles between patients according to transmission patterns of the disease.
conclusionThese results suggest familial aggregation and excess maternal transmission of type 2 diabetes in the Tunisian studied population.
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