ArticleNucleic acids research2007
G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- Effects of ribonucleotides on telomeric G4 formation, dynamics, and initiation of ribonucleotide excision repair by RNase H2.Nucleic acids research · 2026Article
- Nanostructural Modulation of G-Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches.Journal of neurochemistry · 2025Article
- The Epigenomic Features and Potential Functions of PEG- and PDS-Favorable DNA G-Quadruplexes in Rice.International journal of molecular sciences · 2024Article
- G-quadruplex DNA and RNA in cellular senescence.Frontiers in aging · 2024Review
- G-quadruplexes and associated proteins in aging and Alzheimer's disease.Frontiers in aging · 2023Review
- Epigenomic Features and Potential Functions of KInternational journal of molecular sciences · 2022Article
- The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter.Biochemistry · 2020Article
- Role of folding kinetics of secondary structures in telomeric G-overhangs in the regulation of telomere maintenance inThe Journal of biological chemistry · 2020Article
- Formation of G-quadruplex structure in supercoiled DNA under molecularly crowded conditions.RSC advances · 2019Article
- Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function.Seminars in cell & developmental biology · 2019Review
- Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis.Nature reviews. Urology · 2018Review
- Oligomer formation and G-quadruplex binding by purified murine Rif1 protein, a key organizer of higher-order chromatin architecture.The Journal of biological chemistry · 2018Article
- Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase.Molecules (Basel, Switzerland) · 2017Article
- Effect of interior loop length on the thermal stability and pK(a) of i-motif DNA.Biochemistry · 2015Article
- Unraveling secrets of telomeres: one molecule at a time.DNA repair · 2014Review
- An improved model for the hTERT promoter quadruplex.PloS one · 2014Article
- hnRNP A1: the Swiss army knife of gene expression.International journal of molecular sciences · 2013Review
- Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection.Nucleic acids research · 2013Article
- Telomere- and telomerase-interacting protein that unfolds telomere G-quadruplex and promotes telomere extension in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomes in vertebrates are protected at both ends by telomere DNA composed of tandem (TTAGGG)n repeats. DNA replication produces a blunt-ended leading strand telomere and a lagging strand telomere carrying a single-stranded G-rich overhang at its end. The G-rich strand can form G-quadruplex structure in the presence of K+ or Na+. At present, it is not clear whether quadruplex can form in the double-stranded telomere region where the two complementary strands are constrained in close vicinity and quadruplex formation, if possible, has to compete with the formation of the conventional Watson-Crick duplex. In this work, we studied quadruplex formation in oligonucleotides and double-stranded DNA containing both the G- and C-rich sequences to better mimic the in vivo situation. Under such competitive condition only duplex was observed in dilute solution containing physiological concentration of K+. However, quadruplex could preferentially form and dominate over duplex structure under molecular crowding condition created by PEG as a result of significant quadruplex stabilization and duplex destabilization. This observation suggests quadruplex may potentially form or be induced at the blunt end of a telomere, which may present a possible alternative form of structures at telomere ends.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.