ArticleThe Journal of clinical endocrinology and metabolism2007
Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women.
Article in The Journal of clinical endocrinology and metabolism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Functional genomics of human skeletal development and the patterning of height heritability.Cell · 2025Article
- Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system.PloS one · 2018Article
- Circulating IGF1 and IGF2 and SNP genotypes in men and pregnant and non-pregnant women.Endocrine connections · 2014Article
- DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults.Clinical epigenetics · 2012Article
- Relaxed imprinting of IGF2 in peripheral blood cells of patients with a history of prostate cancer.Endocrine connections · 2012Article
- Article
- Developmental origins of adult diseases.Indian journal of endocrinology and metabolism · 2012Article
- Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.The Journal of pediatrics · 2012Article
- Article
- A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.PloS one · 2012Article
- Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes.Pediatric research · 2010Article
- The insulin polymorphism -23Hph increases the risk for type 1 diabetes mellitus in the Romanian population.Genetics and molecular biology · 2010Article
- Dairy intake associates with the IGF rs680 polymorphism to height variation in periadolescent children.European journal of clinical nutrition · 2010Article
- Recent progress in the genetics of common obesity.British journal of clinical pharmacology · 2009Review
- An alternative approach to medical genetics based on modern evolutionary biology. Part 5: epigenetics and genomics.Journal of the Royal Society of Medicine · 2009Review
- The effect of neurohormonal factors, epigenetic factors, and gut microbiota on risk of obesity.Preventing chronic disease · 2009Article
- Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
contextThe IGF2 gene (IGF2) plays a key role in growth and is a candidate for association with obesity. Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent.
objectivesThe aim of this study was primarily to confirm the association with BMI and, secondarily, to study the associations with other indices of body size.
methodsIn a sample of 2797 women and 2203 men aged 39-79 participating in the Norfolk arm of the European Prospective Investigation of Cancer, we genotyped three single nucleotide polymorphisms (SNPs) in the IGF2 gene that were previously associated with BMI [6815 A/T, 1156 T/C (G/A), and 820 G/A (ApaI)].
resultsNo significant associations were observed between these SNPs and BMI. However, all three SNPs were significantly associated with height (P = 0.03 to 0.001). In a backward elimination regression analysis, two SNPs, 1156 T/C (G/A) and 820 G/A, remained independently associated with height (P = 0.003 and P = 0.038, respectively). Haplotype analysis of these two SNPs showed that carriers of the GA haplotype were shorter than carriers of each of the other three haplotypes (P < 0.001 for all comparisons).
conclusionsWe did not confirm the previously reported associations between IGF2 polymorphisms and BMI. However, our results suggest that common variation in the IGF2 gene may be associated with adult height. IGF2 could be considered as a candidate gene for future research on mechanisms for the association between height and chronic diseases, such as cancer, diabetes, and coronary heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.