GuidelineGut2007
Guidelines on the irritable bowel syndrome: mechanisms and practical management.
Guideline in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 262 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
262 citing papers in PubMed, 12 syntheses or guidelines pooled it, 814 citations in OpenAlex.
- Efficacy of Internet-Based Self-Help Interventions for Irritable Bowel Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- European Consensus on Functional Bloating and Abdominal Distension-An ESNM/UEG Recommendations for Clinical Management.United European gastroenterology journal · 2025Guideline
- Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity.World journal of gastroenterology · 2025Pooled it
- Physical activity for treatment of irritable bowel syndrome.The Cochrane database of systematic reviews · 2022Pooled it
- Irritable Bowel Syndrome and Gluten-Related Disorders.Nutrients · 2020Pooled it
- Homeopathy for treatment of irritable bowel syndrome.The Cochrane database of systematic reviews · 2019Pooled it
- Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome.World journal of gastroenterology · 2017Pooled it
- Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis.The American journal of gastroenterology · 2017Pooled it
- Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis.World journal of gastroenterology · 2015Pooled it
- Evidence-based clinical practice guidelines for irritable bowel syndrome.Journal of gastroenterology · 2015Guideline
- Mindfulness-based therapies in the treatment of somatization disorders: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Phenomena associated with sick leave among primary care patients with Medically Unexplained Physical Symptoms: a systematic review.Scandinavian journal of primary health care · 2012Pooled it
- Effect of Oral Intake ofNutrients · 2022Trial
- Return on investment of internet delivered exposure therapy for irritable bowel syndrome: a randomized controlled trial.BMC gastroenterology · 2021Trial
- Trial
- Internet-Delivered Cognitive Behavior Therapy for Young Taiwanese Female Nursing Students with Irritable Bowel Syndrome-A Cluster Randomized Controlled Trial.International journal of environmental research and public health · 2019Trial
- Trial
- Factors associated with poor therapeutic response in outpatients with irritable bowel syndrome: a multicenter study in Japan.Journal of gastroenterology · 2017Trial
- Moxibustion treatment for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized controlled trial.BMC complementary and alternative medicine · 2016Trial
- Co-Administration of Soy Isoflavones and Vitamin D in Management of Irritable Bowel Disease.PloS one · 2016Trial
202 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundIBS affects 5-11% of the population of most countries. Prevalence peaks in the third and fourth decades, with a female predominance.
aimTo provide a guide for the assessment and management of adult patients with irritable bowel syndrome.
methodsMembers of the Clinical Services Committee of The British Society of Gastroenterology were allocated particular areas to produce review documents. Literature searching included systematic searches using electronic databases such as Pubmed, EMBASE, MEDLINE, Web of Science, and Cochrane databases and extensive personal reference databases.
resultsPatients can usefully be classified by predominant bowel habit. Few investigations are needed except when diarrhoea is a prominent feature. Alarm features may warrant further investigation. Adverse psychological features and somatisation are often present. Ascertaining the patients' concerns and explaining symptoms in simple terms improves outcome. IBS is a heterogeneous condition with a range of treatments, each of which benefits a small proportion of patients. Treatment of associated anxiety and depression often improves bowel and other symptoms. Randomised placebo controlled trials show benefit as follows: cognitive behavioural therapy and psychodynamic interpersonal therapy improve coping; hypnotherapy benefits global symptoms in otherwise refractory patients; antispasmodics and tricyclic antidepressants improve pain; ispaghula improves pain and bowel habit; 5-HT(3) antagonists improve global symptoms, diarrhoea, and pain but may rarely cause unexplained colitis; 5-HT(4) agonists improve global symptoms, constipation, and bloating; selective serotonin reuptake inhibitors improve global symptoms.
conclusionsBetter ways of identifying which patients will respond to specific treatments are urgently needed.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.