ArticleClinical & experimental metastasis2007
Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma.
Article in Clinical & experimental metastasis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Preoperative platelet-lymphocyte ratio is an independent prognostic marker and superior to carcinoembryonic antigen in colorectal peritoneal carcinomatosis patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.International journal of clinical oncology · 2017Trial
- Single-cell Profiling Reveals Cooperative Participation ofInternational journal of medical sciences · 2026Article
- Research progress of epithelial-mesenchymal transformation-related transcription factors in peritoneal metastases.Journal of Cancer · 2024Review
- Article
- COM33 suppresses carboplatin-induced epithelial-mesenchymal transition via inhibition of Twist1 in ovarian cancer.Acta biochimica et biophysica Sinica · 2022Article
- Primary and metastatic peritoneal surface malignancies.Nature reviews. Disease primers · 2021Review
- Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior.Breast cancer research and treatment · 2019Article
- p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT.Molecular cancer research : MCR · 2019Article
- KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear‑cell carcinoma cells.Oncology reports · 2018Article
- Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.Oncogene · 2018Article
- IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis.Cancer management and research · 2018Review
- Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator.Oncology letters · 2017Article
- Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models.Nanomedicine : nanotechnology, biology, and medicine · 2017Article
- Multiple biological functions of Twist1 in various cancers.Oncotarget · 2017Review
- Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells.Journal of visualized experiments : JoVE · 2016Article
- Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53.PloS one · 2016Article
- A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression.Molecular cancer · 2015Article
- Current treatment options for colon cancer peritoneal carcinomatosis.World journal of gastroenterology · 2014Review
- TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis.Oncotarget · 2014Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of E-cadherin triggers peritoneal dissemination, leading to an adverse prognosis for most patients with epithelial ovarian carcinoma (EOC). Because TWIST mainly regulates the epithelial-to-mesenchymal transition and is one of the E-cadherin repressors, we investigated the possibility that TWIST expression affects peritoneal metastasis of EOC using siRNA technique. In the present study, we showed a correlation between TWIST expression and EOC cellular morphology. Furthermore, we demonstrated that the suppression of TWIST expression in EOC cells (HEY) alters the cellular morphology from a fibroblastic and motile phenotype to an epithelial phenotype, and inhibits the adhesion of these cells to mesothelial monolayers. To investigate the mechanism by which down-regulation of TWIST leads to inhibition of adhesion to mesothelial cells (MCs), expression of adhesion molecules (CD29, CD44 and CD54) were observed. Moreover, matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase, important markers associated with invasive and metastatic potential, were remarkably reduced. This findings suggests that reduced expression of TWIST suppresses the multistep process of peritoneal dissemination (detachment from the primary lesion, adhesion to MCs and invasion of MCs) and may be a potential therapeutic target for the treatment of this carcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.