ArticleMolecular and cellular biochemistry2007
Osteoblast cytoskeletal modulation in response to compressive stress at physiological levels.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice.Clinical oral investigations · 2021Article
- The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction.Molecular medicine reports · 2020Article
- Mechanical and Mechanosensing Properties of Tumor Affected Bone Cells Were Inhibited via PI3K/Akt Pathway.Journal of bone metabolism · 2019Article
- Role of the ER/NO/cGMP Signaling Pathway in the Promotion of Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells byEvidence-based complementary and alternative medicine : eCAM · 2016Article
- Compression induces Ephrin-A2 in PDL fibroblasts via c-fos.Journal of dental research · 2015Article
- Mechanosensitive mechanisms in transcriptional regulation.Journal of cell science · 2012Review
- Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts.Molecular and cellular biochemistry · 2010Article
- Response of cementoblast-like cells to mechanical tensile or compressive stress at physiological levels in vitro.Molecular biology reports · 2009Article
- Centrifugal forces within usually-used magnitude elicited a transitory and reversible change in proliferation and gene expression of osteoblastic cells UMR-106.Molecular biology reports · 2009Article
- Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts.Molecular and cellular biochemistry · 2009Article
- Effect of Cytoskeletal Disruption on Mechanotransduction of Hydrostatic Pressure by C3H10T1/2 Murine Fibroblasts.The open orthopaedics journal · 2008Article
- The role of extracellular matrix, integrins, and cytoskeleton in mechanotransduction of centrifugal loading.Molecular and cellular biochemistry · 2008Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomechanical force is one of the major epigenetic factors that determine the form and differentiation of skeletal tissues. In this study, osteoblastic cells UMR-106 were exposed to compressive forces at 1000 mustrain and 4000 mustrain via a four-point bending system, and analyzed by MTT and LSCM techniques. Cell proliferation activity decreased shortly after loading but recovered to normal levels within 24 h. And the cytoskeleton depolymerized at first, but then gradually repolymerized. To find out the role of cytoskeleton in mechanotransduction, we examined the relationship between cytoskeleton construction and c-fos expression. A transient stress-induced upregulation in c-fos mRNA and c-Fos protein was discovered when cells were exposed to physiological forces. And the upregulation in c-fos expression was blocked by cytochalasin D (Depolymerizing agent of microfilament). It gave clues that the organization of cytoskeleton was an important link in transcriptional control in response to low-mechanical stimulation.
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