Evidence map›Paper›PMID 17487145›Full record

ReviewNature reviews. Microbiology2007

The unique role of natural killer T cells in the response to microorganisms.

Emmanuel Tupin, Yuki Kinjo, Mitchell Kronenberg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 236 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 1 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 1 synthesis or guideline pooled it, 453 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Priming of CD8Nature neuroscience · 2026
    Article
  5. CD8bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Primordial Cells Bridging the Gap Between Innate and Adaptive Immunity.Advances in experimental medicine and biology · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emmanuel TupinDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA.
Yuki Kinjo
Mitchell Kronenberg
La Jolla Institute for Immunology · US

Funding

Development and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9M
NIAID NIH HHS R37 AI071922
6 · The paper itself

Abstract

Natural killer T (NKT) cells combine features of the innate and adaptive immune systems. Recently, it has become evident that these T cells have crucial roles in the response to infectious agents. The antigen receptor expressed by NKT cells directly recognizes unusual glycolipids that are part of the membrane of certain Gram-negative bacteria and spirochetes. Moreover, even in the absence of microbial glycolipid antigens, these T cells respond to innate cytokines produced by dendritic cells that have been activated by microbes. This indirect sensing of infection, by responding to cytokines from activated dendritic cells, allows NKT cells to react to a broad range of infectious agents.

Indexed as

AnimalsBacteriaBacterial InfectionsCell WallCytokinesDendritic CellsHumansKiller Cells, NaturalReceptors, Antigen, T-CellT-Lymphocyte SubsetsCytokinesReceptors, Antigen, T-Cell

Identifiers

PMID17487145
OpenAlexW2046085625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.