ArticleThe Journal of biological chemistry1991
The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin.
Article in The Journal of biological chemistry, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 117 citations in OpenAlex.
- The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.Comprehensive Physiology · 2021Article
- Article
- Regulation of 130-kDa smooth muscle myosin light chain kinase expression by an intronic CArG element.The Journal of biological chemistry · 2013Article
- Myosin light chain kinase signaling in endothelial barrier dysfunction.Medicinal research reviews · 2013Review
- Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.The Journal of biological chemistry · 2012Article
- An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- Article
- A transcribed pseudogene of MYLK promotes cell proliferation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.Molecular and cellular biology · 2011Article
- Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Redox control of vascular smooth muscle migration.Antioxidants & redox signaling · 2010Review
- Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.The Journal of biological chemistry · 2009Article
- Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues.American journal of physiology. Cell physiology · 2006Review
- Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter.Molecular biology of the cell · 2006Article
- Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1.Molecular and cellular biology · 2005Article
- Telokin mediates Ca2+-desensitization through activation of myosin phosphatase in phasic and tonic smooth muscle.Journal of muscle research and cell motility · 2004Article
- Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts.American journal of physiology. Cell physiology · 2004Article
- Distribution and expression of non-muscle myosin light chain kinase in rabbit livers.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It has been proposed that the carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein. This protein has been purified from tissues and named telokin (Ito, M., Dabrowska, R., Guerriero, V., Jr., and Hartshorne, D. J. (1989) J. Biol. Chem. 264, 13971-13974). In this study we have isolated and characterized cDNA and genomic clones encoding telokin. Analysis of a genomic DNA clone suggests that the mRNA encoding telokin arises from a promoter which appears to be located within an intron of the smooth muscle myosin light chain kinase (MLCK) gene. This intron interrupts exons encoding the calmodulin binding domain of the kinase. The amino acid sequence deduced from the cDNA predicts that telokin is identical to the carboxyl-terminal 155 residues of the smooth muscle MLCK. Unlike the smooth muscle MLCK which is expressed in both smooth and non-muscle tissues, telokin is expressed in some smooth muscle tissues but has not been detected in aortic smooth muscle or in any non-muscle tissues.
Indexed as
Identifiers
1748667PMC2836763W1522388412What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.