ArticleThe Journal of biological chemistry1991
Molecular characterization of a mammalian smooth muscle myosin light chain kinase.
Article in The Journal of biological chemistry, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Hypoxic modulation of fetal vascular MLCK abundance, localization, and function.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases.International journal of molecular sciences · 2020Review
- Activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation.Molecular biology of the cell · 2017Article
- Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives.European biophysics journal : EBJ · 2016Review
- Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.Pharmacological reviews · 2016Review
- Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation.American journal of respiratory cell and molecular biology · 2014Article
- The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton.Cell host & microbe · 2012Article
- Vascular smooth muscle phenotypic diversity and function.Physiological genomics · 2010Review
- Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases.The Journal of cell biology · 2010Article
- Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.Molecular biology of the cell · 2010Article
- Myosin light chain kinase in microvascular endothelial barrier function.Cardiovascular research · 2010Review
- Modular structure of smooth muscle Myosin light chain kinase: hydrodynamic modeling and functional implications.Biochemistry · 2010Article
- Redox control of vascular smooth muscle migration.Antioxidants & redox signaling · 2010Review
- INSIGHTS INTO THE ROLES OF NON-MUSCLE MYOSIN IIA IN HUMAN KERATINOCYTE MIGRATION.Cellular and molecular bioengineering · 2009Article
- Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.PloS one · 2009Article
- Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcription.Gastroenterology · 2009Article
- T cell antigen receptor signaling and immunological synapse stability require myosin IIA.Nature immunology · 2009Article
- Article
- Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues.American journal of physiology. Cell physiology · 2006Review
- Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1.Molecular and cellular biology · 2005Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
A 5.6-kilobase cDNA clone has been isolated which includes the entire coding region for the myosin light chain kinase from rabbit uterine tissue. This cDNA, expressed in COS cells, encodes a Ca2+/calmodulin-dependent protein kinase with catalytic properties similar to other purified smooth muscle myosin light chain kinases. A module (TLKPVGNIKPAE), repeated sequentially 15 times, has been identified near the N terminus of this smooth muscle kinase. It is not present in chicken gizzard or rabbit skeletal muscle myosin light chain kinases. This repeat module and a subrepeat (K P A/V) are similar in amino acid content to repeated motifs present in other proteins, some of which have been shown to associate with chromatin structures. Immunoblot analysis after sodium dodecyl sulfate-polyacrylamide gel electrophoresis, used to compare myosin light chain kinase present in rabbit, bovine, and chicken smooth and nonmuscle tissues, showed that within each species both tissue types have myosin light chain kinases with indistinguishable molecular masses. These data suggest that myosin light chain kinases present in smooth and nonmuscle tissues are the same protein.
Indexed as
Identifiers
1748666PMC2836767What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.