ArticleNeurochemical research2007
Effects of methylprednisolone and hyperbaric oxygen on oxidative status after experimental spinal cord injury: a comparative study in rats.
Article in Neurochemical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Trial
- Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury.Regenerative therapy · 2025Article
- Human Placental Mesenchymal Stem Cell-derived Exosomes in Combination with Hyperbaric Oxygen Synergistically Promote Recovery after Spinal Cord Injury in Rats.Neurotoxicity research · 2023Article
- Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- Synergistic neuroprotective effects of hyperbaric oxygen and methylprednisolone following contusive spinal cord injury in rat.The journal of spinal cord medicine · 2022Article
- Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.Journal of neurotrauma · 2022Article
- Effects of Respiratory Muscle Training on Baroreflex Sensitivity, Respiratory Function, and Serum Oxidative Stress in Acute Cervical Spinal Cord Injury.Journal of personalized medicine · 2021Article
- Alterations in glutathione, nitric oxide and 3-nitrotyrosine levels following exercise and/or hyperbaric oxygen treatment in mice with diet-induced diabetes.Biomedical reports · 2020Article
- Electroacupuncture and Curcumin Promote Oxidative Balance and Motor Function Recovery in Rats Following Traumatic Spinal Cord Injury.Neurochemical research · 2019Article
- Protection from spinal cord ischemia-reperfusion damage with alpha-lipoic acid preconditioning in an animal model.Turk gogus kalp damar cerrahisi dergisi · 2018Article
- Neuroprotective effects of sildenafil in experimental spinal cord injury in rabbits.Bosnian journal of basic medical sciences · 2015Article
- Quercetin promotes neuronal and behavioral recovery by suppressing inflammatory response and apoptosis in a rat model of intracerebral hemorrhage.Neurochemical research · 2015Article
- Anti-apoptotic and anti-oxidative roles of quercetin after traumatic brain injury.Cellular and molecular neurobiology · 2014Article
- Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury.Journal of natural medicines · 2014Article
- Neuroprotective effect of apigenin in rats after contusive spinal cord injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Non-pharmacological experimental treatments for spinal cord injury: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
- The Effect of High Dose Methylprednisolone on Experimental Ovarian Torsion/Reperfusion Injury in Rats.Geburtshilfe und Frauenheilkunde · 2012Article
- Does hypothermic treatment provide an advantage after spinal cord injury until surgery? An experimental study.Neurochemical research · 2009Article
- A review on the neuroprotective effects of hyperbaric oxygen therapy.Medical gas researchReview
- Hyperbaric oxygen therapy of spinal cord injury.Medical gas researchReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of hyperbaric oxygen (HBO) therapy or methylprednisolone on the oxidative status were evaluated in experimental spinal cord injury. Clip compression method was used to produce acute spinal cord injury rats. Hyperbaric oxygen was administered twice daily for a total of eight 90 min-sessions at 2.8 atmospheres. Methylprednisolone was first injected with a bolus of 30 mg/kg followed with an infusion rate of 5.4 mg/kg/h for 24 h. Five days after clip application animals were sacrificed and their traumatized spinal cord segment were excised. Tissue levels of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were evaluated to reflect oxidant/antioxidant status. Non-treated clip-operated animals reflected significantly higher SOD, GSH-Px and TBARS levels that were found to be significantly higher than the sham-operated. Methylprednisolone was not able to lower these levels. HBO administration diminished all measured parameters significantly; however, their levels appeared already to be high when compared with sham animals. According to these results obtained on the 5th day after induction, HBO, but not methylprednisolone, seems to procure prevention against oxidative spinal cord injury.
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