ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage.Breast cancer research : BCR · 2025Article
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- Slc11a1 gene polymorphism influences dextran sulfate sodium (DSS)-induced colitis in a murine model of acute inflammation.Genes and immunity · 2023Article
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- Bioinformatic identification of hub genes and key pathways in neutrophils of patients with acute respiratory distress syndrome.Medicine · 2020Article
- Slc11a1 (Nramp-1) gene modulates immune-inflammation genes in macrophages during pristane-induced arthritis in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Drug-induced regeneration in adult mice.Science translational medicine · 2015Article
- Tendon regeneration and scar formation: The concept of scarless healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Review
- Inflammation and Its Correlates in Regenerative Wound Healing: An Alternate Perspective.Advances in wound care · 2014Review
- Acute Inflammation Loci Are Involved in Wound Healing in the Mouse Ear Punch Model.Advances in wound care · 2014Review
- Trypanosoma cruzi infection in genetically selected mouse lines: genetic linkage with quantitative trait locus controlling antibody response.Mediators of inflammation · 2014Article
- Pristane-induced arthritis loci interact with the Slc11a1 gene to determine susceptibility in mice selected for high inflammation.PloS one · 2014Article
- Keratin gene expression profiles after digit amputation in C57BL/6 vs. regenerative MRL mice imply an early regenerative keratinocyte activated-like state.Physiological genomics · 2013Article
- Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- Distinct early inflammatory events during ear tissue regeneration in mice selected for high inflammation bearing Slc11a1 R and S alleles.Inflammation · 2011Article
- The role of p21 in regulating mammalian regeneration.Stem cell research & therapy · 2011Article
- Article
- Unexpected regeneration in middle-aged mice.Rejuvenation research · 2009Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lines of mice were obtained by selective breeding for maximum (AIRmax) or minimum (AIRmin) acute inflammation. They present distinct neutrophil influx and show frequency disequilibrium of the solute carrier family 11a member 1 (Slc11a1) alleles. This gene is involved in ion transport at the endosomes within macrophages and neutrophils, interfering in their activation. Homozygous AIRmax and AIRmin sublines for the Slc11a1 gene were produced to examine the interaction of this gene with the acute inflammatory loci. The present work investigated wound-healing traits in AIRmax and AIRmin mice, in F(1) and F(2) intercrosses, and in Slc11a1 sublines. Two-millimeter ear punches were made in the mice and hole closure was measured during 40 days. AIRmax mice demonstrated significant tissue repair while AIRmin mice did not. Significant differences between the responses of male and female mice were also observed. Wound-healing traits demonstrated a correlation with neutrophil influx in F(2) populations. AIRmax( SS )showed higher ear-wound closure than AIRmax( RR ) mice, suggesting that the Slc11a1 S allele favored ear tissue repair. QTL analysis has detected two inflammatory loci modulating ear wound healing on chromosomes 1 and 14. These results suggest the involvement of the acute inflammation modifier QTL in the wound-healing phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.