ArticleCurrent microbiology2007
The 2-cys peroxiredoxin-deficient Listeria monocytogenes displays impaired growth and survival in the presence of hydrogen peroxide in vitro but not in mouse organs.
Article in Current microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Investigating the Roles of Listeria monocytogenes Peroxidases in Growth and Virulence.Microbiology spectrum · 2021Article
- Identification of Listeria monocytogenes Genes Contributing to Oxidative Stress Resistance under Conditions Relevant to Host Infection.Infection and immunity · 2021Article
- Food-Associated Stress Primes Foodborne Pathogens for the Gastrointestinal Phase of Infection.Frontiers in microbiology · 2018Review
- Thioredoxin A Is Essential for Motility and Contributes to Host Infection ofFrontiers in cellular and infection microbiology · 2017Article
- Insights into the Function of a Second, Nonclassical Ahp Peroxidase, AhpA, in Oxidative Stress Resistance in Bacillus subtilis.Journal of bacteriology · 2016Article
- Transcriptomic and phenotypic responses of Listeria monocytogenes strains possessing different growth efficiencies under acidic conditions.Applied and environmental microbiology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance of Listeria monocytogenes to reactive oxygen radicals may facilitate its survival in phagocytic cells and against some oxidizing sanitizers. The aim of this study was to investigate the function of the 2-cys peroxiredoxin (Prx) homologue in L. monocytogenes, particularly its survival in a hydrogen peroxide-containing environment. An in-frame prx deletion mutant and a complementation strain were constructed and evaluated for their growth and survival either in media containing different concentrations (0, 15, 20, 25, 50, and 294 mmol x L(-1)) hydrogen peroxide or in macrophages. Bacterial survival in various mouse organs was also investigated after intraperitoneal administration. We found that prx-defective L. monocytogenes was sensitive to hydrogen peroxide in in vitro growth media but not in mouse organs or in macrophages, suggesting that Prx promotes survival in the presence of exogenous hydrogen peroxide but not in mammalian cells or organs.
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Registered trials
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