ArticleJournal of cancer research and clinical oncology2007
Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study.
Article in Journal of cancer research and clinical oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Diagnostic Accuracy of p16 Immunohistochemistry as a Marker of High-Risk HPV in Invasive Laryngeal Squamous Cell Carcinoma: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis.BMC cancer · 2014Pooled it
- GSTM1 null polymorphisms is associated with laryngeal cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review.Head and neck pathology · 2012Pooled it
- Glutathione S-transferase M1 gene polymorphism and laryngeal cancer risk: a meta-analysis.PloS one · 2012Pooled it
- Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis.Journal of cancer research and clinical oncology · 2011Pooled it
- Clinicopathological Characteristics, Treatment Patterns, and Outcomes in Patients with Laryngeal Cancer.Current oncology (Toronto, Ont.) · 2023Article
- Assessment of Human Leukocyte Antigen Differences between Smokers with Reinke's Edema and Those with Laryngeal Cancer.Iranian journal of otorhinolaryngology · 2022Article
- The Down-Regulation of TrkB Alleviates the Malignant Biological Behavior and Cancer Stem-Like Property of Laryngeal Cancer.Cancer management and research · 2020Article
- miR-181a and miR-203 inhibit migration and invasion of laryngeal carcinoma cells by interacting with ATF2.International journal of clinical and experimental pathology · 2019Article
- Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.Oncology letters · 2017Article
- Molecular tests potentially improving HPV screening and genotyping for cervical cancer prevention.Expert review of molecular diagnostics · 2017Review
- Characteristics and outcome of laryngeal squamous cell carcinoma in young adults.Oncology letters · 2017Article
- Clinical impact of human papillomavirus in laryngeal squamous cell carcinoma: a retrospective study.PeerJ · 2017Article
- Review
- Expression and significance of TWIST, a zinc finger transcription factor, in laryngeal carcinoma among Chinese population: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Recurrent respiratory papillomatosis: HPV genotypes and risk of high-grade laryngeal neoplasia.PloS one · 2014Article
- Smoking affects quality of life in patients with oral squamous cell carcinomas.Clinical oral investigations · 2012Article
- Possible implication of Mdm2 as a prognostic marker in invasive laryngeal carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2012Article
- The epidemiology of laryngeal cancer in a country on the esophageal cancer belt.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHuman papillomavirus (HPV) has been linked to oropharyngeal carcinomas, but its role in laryngeal squamous cell carcinoma (LSCC) is not clear. A prospective multicenter study based on known tumor-cell percentage of fresh frozen carcinoma biopsies was established to determine the HPV prevalence. Moreover risk factors such as smoking, alcohol abuse, chronic laryngitis and gastroesophageal reflux disease (GERD) were evaluated
methodsFresh-frozen laryngeal cancer biopsies from 108 patients in Finland, Norway, and Sweden were investigated. Patients whose biopsy samples contained at least 20% tumor tissue (N = 69) entered the study. HPV DNA was determined with MY09/11 and GP5+/6+ nested PCR and SPF10 PCR hybridization assay. Patients were examined by an ENT specialist and an extensive questionnaire concerning risk factors was filled in.
resultsOnly three patients (4.4%) harbored HPV DNA in their carcinoma sample. Heavy alcohol drinking was associated with an increased risk of death, advanced-stage disease, and younger age at diagnosis. Chronic laryngitis, GERD, and orogenital sex contacts were rare. Poor oral hygiene was not associated with survival, although it correlated with heavy drinking.
conclusionIn our series HPV was not important in LSCC. Heavy drinking led to major mortality in LSCC and promoted early carcinogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.