Trial reportIntensive care medicine2007
Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography.
Trial report in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 213 citations in OpenAlex.
- Renal resistive index-guided mean arterial pressure titration in sepsis: a prospective single-center, single-blind, parallel-group randomized controlled trial.Nature communications · 2026Trial
- Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial.Intensive care medicine · 2025Trial
- Effects of changes in position, positive end-expiratory pressure and mean arterial pressure on renal, portal and hepatic Doppler ultrasound perfusion indices: a randomized crossover study in cardiac surgery patients.Journal of clinical monitoring and computing · 2022Trial
- Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study.Critical care (London, England) · 2009Trial
- Combined plasma syndecan-1 and renal resistive index as early predictors of sepsis-associated Acute kidney injury: a prospective observational study.Renal failure · 2026Observational
- ARISE framework: a temporal, multi-organ view of perfusion in sepsis.Internal and emergency medicine · 2026Review
- Article
- Contrast-enhanced ultrasound and elastography predict histopathology and recovery in acute kidney injury.Renal failure · 2025Article
- Renal Resistive Index from Renal Hemodynamics to Cardiovascular Risk: Diagnostic, Prognostic, and Therapeutic Implications.Diseases (Basel, Switzerland) · 2025Review
- Exploring the Utility of Renal Resistive Index in Critical Care: Insights into ARDS and Cardiac Failure.Biomedicines · 2025Review
- Kidney point-of-care ultrasonography in the PICU: it is about time!Pediatric nephrology (Berlin, Germany) · 2024Article
- Linear Correlation Between Mean Arterial Pressure and Urine Output in Critically Ill Patients.Critical care explorations · 2024Observational
- Renal and Genitourinary Ultrasound Evaluation in Emergency and Critical Care: An Overview.Healthcare (Basel, Switzerland) · 2024Review
- Acute kidney injury in children undergoing cardiac surgery: predictive value of kidney arterial Doppler-based variables.Pediatric nephrology (Berlin, Germany) · 2024Article
- Impact of Norepinephrine and Dopamine Infusion on Renal Arterial Resistive Index during Pre-Emptive Living Donor Kidney Transplantation: Propensity Score Matching Analysis.Medicina (Kaunas, Lithuania) · 2024Observational
- Prediction of Acute Kidney Injury After Cardiac Surgery With Combined Arterial and Venous Intrarenal Doppler.Canadian journal of kidney health and disease · 2024Article
- Study on the Predictive Value of Renal Resistive Index Combined with β2-Microglobulin in Patients with Urosepsis Complicated with Acute Kidney Injury.Journal of inflammation research · 2024Article
- Transcending boundaries: Unleashing the potential of multi-organ point-of-care ultrasound in acute kidney injury.World journal of nephrology · 2023Review
- Influence of arterial blood gases on the renal arterial resistive index in intensive care unit.Journal of translational medicine · 2023Observational
- Renal arterial resistive index, monocyte chemotactic protein 1 and neutrophil gelatinase-associated lipocalin, for predicting acute kidney injury in critically ill cancer patients.International urology and nephrology · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effects of increasing mean arterial pressure (MAP) on renal resistances assessed by Doppler ultrasonography in septic shock. DESIGN AND
settingProspective, single-center, nonrandomized, open-label trial in the surgical intensive care unit in a university teaching hospital. PATIENTS AND
participants11 patients with septic shock who required fluid resuscitation and norepinephrine to increase and maintain MAP at or above 65 mmHg.
interventionsNorepinephrine was titrated in 11 patients in septic shock during three consecutive not randomized periods of 2 h to achieve a MAP at successively 65, 75, and 85 mmHg. MEASUREMENTS AND
resultsAt the end of each period hemodynamic parameters and renal function variables (urinary output, creatinine, clearance) were measured, and Doppler ultrasonography was performed on interlobar arteries to assess the renal resistive index. When increasing MAP from 65 to 75 mmHg, urinary output increased significantly from 76 +/- 64 to 93 +/- 68 ml/h and the resistive index significantly decreased from 0.75 +/- 0.07 to 0.71 +/- 0.06. No difference was found between 75 and 85 mmHg.
conclusionsDoppler ultrasonography and resistive index measurements may help determine in each patient the optimal MAP for renal blood flow and may be a relevant end-point to titrate the hemodynamic treatment in septic shock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.