ArticleMolecular systems biology2007
Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.
Article in Molecular systems biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 68 citations in OpenAlex.
- Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus.Proteome science · 2023Article
- Article
- Bringing New Methods to the Seed Proteomics Platform: Challenges and Perspectives.International journal of molecular sciences · 2020Review
- Integrating multiomics longitudinal data to reconstruct networks underlying lung development.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Preventing bronchopulmonary dysplasia: new tools for an old challenge.Pediatric research · 2019Review
- Comprehensive Cis-Regulation Analysis of Genetic Variants in Human Lymphoblastoid Cell Lines.Frontiers in genetics · 2019Article
- Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.Cell death & disease · 2018Article
- Time-resolved proteome profiling of normal lung development.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Physiological and proteomic analyses of the drought stress response in Amygdalus Mira (Koehne) Yü et Lu roots.BMC plant biology · 2017Article
- Article
- Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples.Scientific reports · 2016Article
- Regulation of alveolar septation by microRNA-489.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- NeuCode labels for relative protein quantification.Molecular & cellular proteomics : MCP · 2014Article
- Primate transcript and protein expression levels evolve under compensatory selection pressures.Science (New York, N.Y.) · 2013Article
- Systems biology approaches to identify developmental bases for lung diseases.Pediatric research · 2013Review
- Tools for label-free peptide quantification.Molecular & cellular proteomics : MCP · 2013Review
- Identification of prostate-enriched proteins by in-depth proteomic analyses of expressed prostatic secretions in urine.Journal of proteome research · 2012Article
- Effects of aging and anatomic location on gene expression in human retina.Frontiers in aging neuroscience · 2012Article
- Article
- Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia.Molecular & cellular proteomics : MCP · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although microarray analysis has provided information regarding the dynamics of gene expression during development of the mouse lung, no extensive correlations have been made to the levels of corresponding protein products. Here, we present a global survey of protein expression during mouse lung organogenesis from embryonic day E13.5 until adulthood using gel-free two-dimensional liquid chromatography coupled to shotgun tandem mass spectrometry (MudPIT). Mathematical modeling of the proteomic profiles with parallel DNA microarray data identified large groups of gene products with statistically significant correlation or divergence in coregulation of protein and transcript levels during lung development. We also present an integrative analysis of mRNA and protein expression in Nmyc loss- and gain-of-function mutants. This revealed a set of 90 positively and negatively regulated putative target genes. These targets are evidence that Nmyc is a regulator of genes involved in mRNA processing and a repressor of the imprinted gene Igf2r in the developing lung.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.