ArticleProceedings of the National Academy of Sciences of the United States of America2007
Evidence for mutation showers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 75 citations in OpenAlex.
- Analyzing somatic mutations by single-cell whole-genome sequencing.Nature protocols · 2024Review
- Analysis of Somatic Mutations in Senescent Cells Using Single-Cell Whole-Genome Sequencing.Aging biology · 2023Article
- Identification of a signature of evolutionarily conserved stress-induced mutagenesis in cancer.Frontiers in genetics · 2022Article
- Postzygotic Somatic Mutations in the Human Brain Expand the Threshold-Liability Model of Schizophrenia.Frontiers in psychiatry · 2020Review
- Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Homologous Recombination and the Formation of Complex Genomic Rearrangements.Trends in cell biology · 2019Review
- Spatial statistical tools for genome-wide mutation cluster detection under a microarray probe sampling system.PloS one · 2018Article
- Contributions of Zea mays subspecies mexicana haplotypes to modern maize.Nature communications · 2017Article
- Clusters of Multiple Mutations: Incidence and Molecular Mechanisms.Annual review of genetics · 2015Review
- AID/APOBEC deaminases and cancer.Oncoscience · 2015Review
- Hypermutation in human cancer genomes: footprints and mechanisms.Nature reviews. Cancer · 2014Review
- Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
- Do mutator mutations fuel tumorigenesis?Cancer metastasis reviews · 2013Review
- The rate of spontaneous mutations in human myeloid cells.Mutation research · 2013Article
- Prevalence of multinucleotide replacements in evolution of primates and Drosophila.Molecular biology and evolution · 2013Article
- Endogenous mutagenesis in recombinant sulfolobus plasmids.Journal of bacteriology · 2013Article
- Article
- Two mechanisms produce mutation hotspots at DNA breaks in Escherichia coli.Cell reports · 2012Article
- Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.Molecular cell · 2012Article
- Article
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9 authors at 2 institutions in 3 countries.
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Abstract
Mutants in the Big Blue transgenic mouse system show spontaneous clustered multiple mutations with unexpectedly high frequency, consistent with chronocoordinate events. We tested the prediction that the multiple mutations seen within the lacI mutation target sometimes occur in the context of chronocoordinate multiple mutations spanning multiple kilobases (mutation showers). Additional sequencing of mutants was performed in regions immediately flanking the lacI region (total of 10.7 kb). Nineteen additional mutations were found outside the lacI region ("ectomutations") from 10 mutants containing two or more lacI mutations, whereas only one ectomutation was found in 130 mutants with a single mutation (P < 0.0001). The mutation showers had an average of approximately one mutation per 3 kb. Four mutants showed closely spaced double mutations in the new sequence, and analysis of the spacing between these mutations revealed significant clustering (P = 0.0098). To determine the extent of the mutation showers, regions (8.5 kb total) remote from the lacI region (approximately 16-17 kb away) were sequenced. Only two additional ectomutations were found in these remote regions, consistent with mutation showers that generally do not extend more than approximately 30 kb. We conclude that mutation showers exist and that they constitute at least 0.2% and possibly 1% or more of mutational events observed in this system. The existence of mutation showers has implications for oncogenesis and evolution, raising the possibilities of "cancer in an instant" and "introns as sponges to reduce the deleterious impact of mutation showers."
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.