ArticleAntimicrobial agents and chemotherapy2007
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
Article in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The antiarrhythmic drugs amiodarone and dronedarone inhibit intoxication of cells with pertussis toxin.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Inhibition of Clostridioides difficile toxins TcdA and TcdB by the amiodarone derivative dronedarone.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins ofFrontiers in pharmacology · 2024Article
- Article
- Cyclodextrins in the antiviral therapy.Journal of drug delivery science and technology · 2021Review
- Inhibition of Pore-Forming Proteins.Toxins · 2019Review
- Article
- An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.Expert opinion on investigational drugs · 2015Review
- Designing inhibitors of anthrax toxin.Expert opinion on drug discovery · 2014Review
- Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.Nature chemical biology · 2013Article
- Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.ACS chemical biology · 2013Article
- Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.Biochemical pharmacology · 2011Article
- Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis.The open microbiology journal · 2010Article
- The overlap of small molecule and protein binding sites within families of protein structures.PLoS computational biology · 2010Article
- Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.Bioorganic & medicinal chemistry · 2009Article
- Novel strategies to combat bacterial virulence.Current opinion in critical care · 2008Review
- Targeting virulence: a new paradigm for antimicrobial therapy.Nature chemical biology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Anthrax lethal toxin is one of the fundamental components believed to be responsible for the virulence of Bacillus anthracis. In order to find novel compounds with anti-lethal toxin properties, we used a cell-based assay to screen a collection of approximately 500 small molecules. Nineteen compounds that blocked lethal toxin-mediated killing of RAW 264.7 macrophages were identified, and we report here on the characterization of the two most potent antitoxic compounds, amiodarone and bepridil. These drugs are used to treat cardiac arrhythmia or angina in humans at doses similar to those that provide protection against lethal toxin in vitro. Our results support a model whereby the antitoxic properties of both drugs result from their ability to block endosomal acidification, thereby blocking toxin entry. Amiodarone was tested in vivo and found to significantly increase survival of lethal toxin-challenged Fischer rats.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.