ArticleMolecular and cellular biology2007
A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons.Communications biology · 2022Article
- Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior.Journal of pineal research · 2022Article
- Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland.Journal of pineal research · 2020Article
- Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon.Frontiers in neuroscience · 2020Article
- Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish.Communications biology · 2019Article
- The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans.International journal of molecular sciences · 2016Article
- The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus.Brain structure & function · 2015Article
- Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland.BioMed research international · 2014Review
- Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus.Developmental biology · 2013Article
- Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance.Molecular and cellular biology · 2013Article
- Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.Neurochemical research · 2013Review
- Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse.Human molecular genetics · 2012Article
- Xenopus Bsx links daily cell cycle rhythms and pineal photoreceptor fate.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate in vivo roles of a murine hypothalamic homeobox gene, Bsx, we generated and analyzed two mutant alleles, Bsx(DeltaHD) and Bsx(lacZ). Bsx(DeltaHD) lacks the homeodomain, and Bsx(lacZ) is an insertion of a lacZ reporter gene. Bsx-lacZ expression was detected in the hypothalamus and pineal gland and reiterates Bsx expression. Bsx homozygous mutant mice were born at the expected Mendelian ratio, but their growth was impaired. Offspring from Bsx homozygous mutant females exhibited a low survival rate due to a nursing defect. Mammary glands of the mutant females developed normally during pregnancy; however, they involuted quickly after parturition. These results demonstrate that Bsx is required for postnatal growth and maintenance of lactating mammary glands. Thus, mouse Bsx is likely involved in systemic control of suppression of apoptosis of postpartum mammary epithelial cells.
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