ArticleImmunology2007
Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter.
Article in Immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Low-avidity T cells drive endogenous tumor immunity in mice and humans.Nature immunology · 2025Article
- miR-155 Overexpression in OT-1 CD8Molecular therapy oncolytics · 2020Article
- Immune Signature of Enhanced Functional Avidity CD8Scientific reports · 2017Article
- Comparative Immunogenicity in Rabbits of the Polypeptides Encoded by the 5' Terminus of Hepatitis C Virus RNA.Journal of immunology research · 2015Article
- Review
- CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals.PloS one · 2014Article
- In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection.Viral immunology · 2013Article
- Modulation of MHC binding by lateral association of TCR and coreceptor.Biophysical journal · 2012Article
- Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment.PloS one · 2012Article
- Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)β-mediated suppression.Cancer immunology, immunotherapy : CII · 2011Article
- Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.Immunology · 2011Article
- Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes.AIDS (London, England) · 2010Article
- Dendritic cells reveal a broad range of MHC class I epitopes for HIV-1 in persons with suppressed viral load on antiretroviral therapy.PloS one · 2010Article
- Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.Journal of virology · 2010Article
- CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturation.Virology · 2009Article
- Review
- Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The generation of an optimal CD8(+) cytotoxic T lymphocyte (CTL) response is critical for the clearance of many intracellular pathogens. Previous studies suggest that one contributor to an optimal immune response is the presence of CD8(+) cells exhibiting high functional avidity. In this regard, CD8 expression has been shown to contribute to peptide sensitivity. Here, we investigated the ability of naive splenocytes to modulate CD8 expression according to the concentration of stimulatory peptide antigen. Our results showed that the level of CD8 expressed was inversely correlated with the amount of peptide used for the primary stimulation, with higher concentrations of antigen resulting in lower expression of both CD8alpha and CD8beta. Importantly the ensuing CD8(low) and CD8(high) CTL populations were not the result of the selective outgrowth of naive CD8(+) T-cell subpopulations expressing distinct levels of CD8. Subsequent encounter with peptide antigen resulted in continued modulation of both the absolute level and the isoform of CD8 expressed and in the functional avidity of the responding cells. We propose that CD8 cell surface expression is not a static property, but can be modulated to 'fine tune' the sensitivity of responding CTL to a defined concentration of antigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.