ArticleMolecular and cellular biochemistry2007
Gonadotropic regulation of circadian clockwork in rat granulosa cells.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- CLOCK inhibits the proliferation of porcine ovarian granulosa cells by targeting ASB9.Journal of animal science and biotechnology · 2023Article
- Regionality of short and long period oscillators in the suprachiasmatic nucleus and their manner of synchronization.PloS one · 2022Article
- Melatonin, Clock Genes, and Mammalian Reproduction: What Is the Link?International journal of molecular sciences · 2021Review
- Circadian rhythms in the mouse reproductive axis during the estrous cycle and pregnancy.Journal of neuroscience research · 2021Article
- Vasopressinergic Activity of the Suprachiasmatic Nucleus and mRNA Expression of Clock Genes in the Hypothalamus-Pituitary-Gonadal Axis in Female Aging.Frontiers in endocrinology · 2021Article
- Juvenile hormone affects the development and strength of circadian rhythms in young bumble beeNeurobiology of sleep and circadian rhythms · 2020Article
- The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.Annual review of cell and developmental biology · 2020Review
- Clock control of mammalian reproductive cycles: Looking beyond the pre-ovulatory surge of gonadotropins.Reviews in endocrine & metabolic disorders · 2020Review
- Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis.Molecular and cellular endocrinology · 2020Review
- Rhythms in the endocrine system of fish: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Effect of lipopolysaccharide on circadian clock genes Per2 and Bmal1 in mouse ovary.The journal of physiological sciences : JPS · 2017Article
- Observation of the dynamics of follicular development in the ovary.Reproductive medicine and biology · 2017Review
- Dim light at night disturbs the daily sleep-wake cycle in the rat.Scientific reports · 2016Article
- Effects of BMAL1-SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS.Endocrine · 2016Article
- Neuroendocrine underpinnings of sex differences in circadian timing systems.The Journal of steroid biochemistry and molecular biology · 2016Review
- The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells.Physiological reports · 2016Article
- A Multi-Oscillatory Circadian System Times Female Reproduction.Frontiers in endocrinology · 2015Review
- Cooperation of luteinizing hormone signaling pathways in preovulatory avian follicles regulates circadian clock expression in granulosa cell.Molecular and cellular biochemistry · 2014Article
- REV-ERBα inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids.The Journal of reproduction and development · 2014Article
- The Interplay between Circadian System, Cholesterol Synthesis, and Steroidogenesis Affects Various Aspects of Female Reproduction.Frontiers in endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock is responsible for the generation of circadian rhythms in hormonal secretion and metabolism. These peripheral clocks could be reset by various cues in order to adapt to environmental variations. The ovary can be characterized as having highly dynamic physiology regulated by gonadotropins. Here, we aimed to address the status of circadian clock in the ovary, and to explore how gonadotropins could regulate clockwork in granulosa cells (GCs). To this end, we mainly utilized the immunohistochemistry, RT-PCR, and real-time monitoring of gene expression methods. PER1 protein was constantly abundant across the daily cycle in the GCs of immature ovaries. In contrast, PER1 protein level was obviously cyclic through the circadian cycle in the luteal cells of pubertal ovaries. In addition, both FSH and LH induced Per1 expression in cultured immature and mature GCs, respectively. The promoter analysis revealed that the Per1 expression was mediated by the cAMP response element binding protein. In cultured transgenic GCs, both FSH and LH also induced the circadian oscillation of Per2. However, the Per2 oscillation promoted by FSH quickly dampened within only one cycle, whereas the Per2 oscillation promoted by LH was persistently maintained. Collectively, these findings strongly suggest that both FSH and LH play an important role in regulating circadian clock in the ovary; however, they might exert differential actions on the clockwork in vivo due to each specific role within ovarian physiology.
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