ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2007
Precision and accuracy of measuring changes in bone mineral density by dual-energy X-ray absorptiometry.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of osteoporosis in healthy adult males in India measured by dual-energy-X-ray absorptiometry: A systematic review and meta-analysis.The Indian journal of medical research · 2026Pooled it
- Effects of whole body vibration in postmenopausal osteopenic women on bone mineral density, muscle strength, postural control and quality of life: the T-bone randomized trial.European journal of applied physiology · 2022Trial
- Effects of whole body vibration on bone mineral density and falls: results of the randomized controlled ELVIS study with postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Trial
- Effects of romosozumab on the peripheral and axial skeleton in postmenopausal women at high fracture risk: real-world evidence from DXA and HR-pQCT data.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Association between triglyceride glucose index and odds of hip fracture in patients with or without type 2 diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Central and peripheral areal BMD, bone microarchitecture, and strength after initiation of androgen deprivation therapy in men with prostate cancer: a two-year follow-up study.Frontiers in endocrinology · 2026Observational
- Reproducibility of CT-based opportunistic vertebral volumetric bone mineral density measurements from an automated segmentation framework.European radiology experimental · 2024Article
- Fatty infiltration of the multifidus muscle independently increases osteoporotic vertebral compression fracture risk.BMC musculoskeletal disorders · 2023Article
- Evaluation of the bone mineral density in the Mexican female population using the Radiofrequency Echographic Multi Spectrometry (REMS) technology.Archives of osteoporosis · 2022Article
- Update on Imaging-Based Measurement of Bone Mineral Density and Quality.Current rheumatology reports · 2020Review
- "Sex" and body region effects on bone mineralization in male pigs.Archives animal breeding · 2020Article
- The impact of vitamin D levels on glycemic control and bone mineral density in postmenopausal women with type 2 diabetes.Journal of endocrinological investigation · 2015Article
- The measurement of bone mineral density of bilateral proximal humeri using DXA in patients with unilateral rotator cuff tear.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Knee flexion influences periprosthetic BMD measurement in the tibia. Suggestions for a reproducible clinical scan protocol.Acta orthopaedica · 2010Article
- Dual energy x-ray absorptiometry of the distal femur may be more reliable than the proximal tibia in spinal cord injury.Archives of physical medicine and rehabilitation · 2009Article
- Bone markers and their prognostic value in metastatic bone disease: clinical evidence and future directions.Cancer treatment reviews · 2008Review
- Comment on Tothill and Hannan: precision and accuracy of measuring changes in bone mineral density by dual-energy X-ray absorptiometry.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
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Abstract
unlabelledLong-term precision of two Hologic DXA scanners was derived from repeated clinical measurements. With typical subjects, the long-term coefficients of variation were about twice the short-term. The accuracy of the measurement of changes was compromised by anomalies, but this did not seriously affect clinical conclusions.
introductionLong-term precision and accuracy of BMD measurements need review.
methodsLong-term precision was examined by selecting, from Hologic databases, subjects who had had four scans over a period of 2 to 5 years and was calculated from the SEE of a regression of BMD against time. Accuracy was assessed from relationships between changes (delta) in BA, BMD and BMC.
resultsFor one group of subjects, the long-term precision was 2.4% for lumbar spine, 2.3% for total hip and 2.7% for femoral neck when expressed as CVs. These values were nearly twice the short-term CVs of 1.3% for spine, 1.2% for total hip and 1.4% for femoral neck. For another group, a negative exponential regression gave a better fit, leading to CVs of 1.3% for the spine, 1.4% for total hip and 2.1% for femoral neck. Significant correlations between deltaBA and deltaBMC were found. These led to an underestimate of deltaBMD in spine and hip by 25%.
conclusionsThe poorer long-term precision for typical patients should be borne in mind in monitoring progress. The underestimate of changes could account for only a part of the underestimation by BMD measurements of the anti-fracture effects of anti-resorptive drugs.
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