ArticleNucleic acids research2007
Distributed control for recruitment, scanning and subunit joining steps of translation initiation.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Multisite rate control analysis identifies ribosomal scanning as the sole high-capacity/low-flux-control step in mRNA translation.The FEBS journal · 2020Article
- Deciphering the rules by which dynamics of mRNA secondary structure affect translation efficiency in Saccharomyces cerevisiae.Nucleic acids research · 2014Article
- An in vivo control map for the eukaryotic mRNA translation machinery.Molecular systems biology · 2013Article
- Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview.Computational and structural biotechnology journal · 2012Review
- Yeast 18 S rRNA is directly involved in the ribosomal response to stringent AUG selection during translation initiation.The Journal of biological chemistry · 2010Article
- Translation initiation factors are not required for Dicistroviridae IRES function in vivo.RNA (New York, N.Y.) · 2009Article
- Control of translation initiation: a model-based analysis from limited experimental data.Journal of the Royal Society, Interface · 2009Article
- A quantitative estimation of the global translational activity in logarithmically growing yeast cells.BMC systems biology · 2008Article
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Authors and funding
3 authors.
Funding
Abstract
Protein synthesis utilizes a large proportion of the available free energy in the eukaryotic cell and must be precisely controlled, yet up to now there has been no systematic rate control analysis of the in vivo process. We now present a novel study of rate control by eukaryotic translation initiation factors (eIFs) using yeast strains in which chromosomal eIF genes have been placed under the control of the tetO7 promoter system. The results reveal that, contrary to previously published reports, control of the initiation pathway is distributed over all of the eIFs, whereby rate control (the magnitude of their respective component control coefficients) follows the order: eIF4G > eIF1A > eIF4E > eIF5B. The apparent rate control effects of eIFs observed in standard cell-free extract experiments, on the other hand, do not accurately reflect the steady state in vivo data. Overall, this work establishes the first quantitative control framework for the study of in vivo eukaryotic translation.
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