ArticleProceedings of the National Academy of Sciences of the United States of America2007
Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 134 citations in OpenAlex.
- Nutrition and Developmental Origins of Kidney Disease.Nutrients · 2023Review
- The social formation of fitness: lifetime consequences of prenatal nutrition and postnatal care in a wild mammal population.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- The Long-Term Effects of Prenatal Hypoxia on Coronary Artery Function of the Male and Female Offspring.Biomedicines · 2022Article
- Effects of developmental and adult environments on ageing.Evolution; international journal of organic evolution · 2022Article
- Change of pace: How developmental tempo varies to accommodate failed provision of early needs.Neuroscience and biobehavioral reviews · 2021Review
- Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage.Obesity science & practice · 2021Article
- Maternal high protein-diet programs impairment of offspring's bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts.Cellular and molecular life sciences : CMLS · 2021Article
- Differential impacts of late gestational over-and undernutrition on adipose tissue traits and associated visceral obesity risk upon exposure to a postnatal high-fat diet in adolescent sheep.Physiological reports · 2020Article
- Dietary protein restriction throughout intrauterine and postnatal life results in potentially beneficial myocardial tissue remodeling in the adult mouse heart.Scientific reports · 2019Article
- Is Foetal Programming by Mismatched Pre- and Postnatal Nutrition Contributing to the Prevalence of Obesity in Nepal?Preventive nutrition and food science · 2019Review
- Altered vertebral and femoral bone structure in juvenile offspring of microswine subject to maternal low protein nutritional challenge.Physiological reports · 2019Article
- The effect of Chinese famine exposure in early life on dietary patterns and chronic diseases of adults.Public health nutrition · 2019Article
- Intrauterine growth restriction results in persistent vascular mismatch in adulthood.The Journal of physiology · 2018Article
- Prenatal Lipopolysaccharide Exposure Promotes Dyslipidemia in the Male Offspring Rats.Frontiers in physiology · 2018Article
- Maternal Macronutrient Consumption and the Developmental Origins of Metabolic Disease in the Offspring.International journal of molecular sciences · 2017Review
- Gender and social mobility modify the effect of birth weight on total and central obesity.Nutrition journal · 2017Article
- Impacts of prenatal nutrition on animal production and performance: a focus on growth and metabolic and endocrine function in sheep.Journal of animal science and biotechnology · 2017Review
- Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance.PLoS genetics · 2016Article
- Long-Term Effects of Prenatal Exposure to Undernutrition on Cannabinoid Receptor-Related Behaviors: Sex and Tissue-Specific Alterations in the mRNA Expression of Cannabinoid Receptors and Lipid Metabolic Regulators.Frontiers in behavioral neuroscience · 2016Article
- The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5.Microorganisms · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit to the fetus, but the long-term effects of these adaptations may prove detrimental if nutrition in postnatal life does not match that predicted by the fetus on the basis of its prenatal environment. We tested this predictive adaptive response hypothesis with respect to CV function in sheep. We observed that a mismatch between pre- and postnatal nutrient environments induced an altered CV function in adult male sheep that was not seen when environments were similar. Sheep that received postnatal undernutrition alone had altered growth, CV function, and basal hypothalamo-pituitary-adrenal axis activity in adulthood. Prenatal undernutrition induced greater weight gain by weaning compared with the prenatal control diet, which may provide a reserve in the face of a predicted poor diet in later life. In an adequate postnatal nutrient environment (i.e., relatively mismatched), these offspring exhibited cardiac hypertrophy and altered CV function in adulthood. These data support the concept that adult CV function can be determined by developmental responses to intrauterine nutrition made in expectation of the postnatal nutritional environment, and that if these predictions are not met, the adult may be maladapted and at greater risk of CV disease. Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.