ArticleProceedings of the National Academy of Sciences of the United States of America2007
Decondensing the protamine domain for transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.The world journal of men's health · 2025Review
- Silent cells? Potential for context-dependent gene expression in mature sperm.Proceedings. Biological sciences · 2025Review
- Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin.Nucleic acids research · 2023Article
- Article
- Human Sperm Chromosomes: To Form Hairpin-Loops, Or Not to Form Hairpin-Loops, That Is the Question.Genes · 2019Article
- Chips off the Old Block: How a Father's Preconception Exposures Might Affect the Health of His Children.Environmental health perspectives · 2018Article
- Nuclease Footprints in Sperm Project Past and Future Chromatin Regulatory Events.Scientific reports · 2016Article
- Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.The Journal of cell biology · 2015Article
- Histone H3.3 regulates dynamic chromatin states during spermatogenesis.Development (Cambridge, England) · 2014Article
- The nuclear form of glutathione peroxidase 4 colocalizes and directly interacts with protamines in the nuclear matrix during mouse sperm chromatin assembly.Spermatogenesis · 2014Article
- Distinct DNA methylation dynamics of spermatogenic cell-specific intronless genes is associated with CpG content.PloS one · 2012Article
- Mechanical regulation of nuclear structure and function.Annual review of biomedical engineering · 2012Review
- Topoisomerase IIbeta is required for lamina-specific targeting of retinal ganglion cell axons and dendrites.Development (Cambridge, England) · 2011Article
- The sperm nucleus: chromatin, RNA, and the nuclear matrix.Reproduction (Cambridge, England) · 2011Review
- Silencing by nuclear matrix attachment distinguishes cell-type specificity: association with increased proliferation capacity.Nucleic acids research · 2009Article
- Differential nuclear scaffold/matrix attachment marks expressed genes.Human molecular genetics · 2009Article
- Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states.Gene therapy & molecular biology · 2009Article
- Topoisomerase IIbeta activates a subset of neuronal genes that are repressed in AT-rich genomic environment.PloS one · 2008Article
- Tracking chromatin states using controlled DNase I treatment and real-time PCR.Cellular & molecular biology letters · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Potentiation is the transition from higher-order, transcriptionally silent chromatin to a less condensed state requisite to accommodating the molecular elements required for transcription. To examine the underlying mechanism of potentiation an approximately 13.7-kb mouse protamine domain of increased nuclease sensitivity flanked by 5' and 3' nuclear matrix attachment regions was defined. The potentiated DNase I-sensitive region is formed at the pachytene spermatocyte stage with the recruitment to the nuclear matrix of a large approximately 9.6-kb region just upstream of the domain. Attachment is then specified in the transcribing round spermatid, recapitulating the organization of the human cluster. In comparison to other modifiers that have no effect, i.e., histone methylation, HP1, and SATB1, topoisomerase engages nuclear matrix binding as minor marks of histone acetylation appear. Reorganization is marked by specific sites of topoisomerase II activity that are initially detected in leptotene-zygotene spermatocytes just preceding the formation of the DNase I-sensitive domain. This has provided a likely model of the events initiating potentiation, i.e., the opening of a chromatin domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.