Evidence map›Paper›PMID 17483433›Full record

ArticleGenetics2007

Bayesian multiple quantitative trait loci mapping for complex traits using markers of the entire genome.

Hanwen Huang, Chevonne D Eversley, David W Threadgill, Fei Zou

Abstract read
In one paragraph

Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hanwen HuangDepartment of Biostatistics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA.
Chevonne D Eversley
David W Threadgill
Fei Zou

Funding

Modeling heterogeneity for safe cancer prevention and detectionU01CA105417 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2004 to 2013
$6.7M
Genetic control of colorectal cancer histopathologyR01CA079869 · NCI · VANDERBILT UNIVERSITY · PI THREADGILL, DAVID W. · 1999 to 2013
$2.7M
Robust Methods for Complex Trait Mapping with Collaborative CrossR01GM074175 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZOU, FEI · 2006 to 2014
$1.7M
Statistical Analysis of RIX for Complex TraitsR03MH070504 · NIMH · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI ZOU, FEI · 2004 to 2005
$144k
NCI NIH HHS CA 079869NCI NIH HHS CA 105417NCI NIH HHS R01 CA079869NCI NIH HHS U01 CA105417NIGMS NIH HHS GM 074175NIGMS NIH HHS R01 GM074175NIMH NIH HHS MH 070504NIMH NIH HHS R03 MH070504
6 · The paper itself

Abstract

A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.

Indexed as

Bayes TheoremQuantitative Trait LociAnimalsChromosome MappingColorectal NeoplasmsGenetic MarkersGenomicsMiceModels, GeneticModels, StatisticalGenetic Markers

Identifiers

PMID17483433
PMCPMC1950652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.