ArticleGenetics2007
Patterns of recombination and MLH1 foci density along mouse chromosomes: modeling effects of interference and obligate chiasma.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Double jeopardy: howFrontiers in cell and developmental biology · 2026Review
- Recombination plasticity in response to temperature variation in reptiles.PLoS genetics · 2025Article
- Diversity and determinants of recombination landscapes in flowering plants.PLoS genetics · 2022Article
- Meiotic Crossover Patterning.Frontiers in cell and developmental biology · 2021Review
- A novel function for CDK2 activity at meiotic crossover sites.PLoS biology · 2020Article
- Crossover Interference: Shedding Light on the Evolution of Recombination.Annual review of genetics · 2019Review
- Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission.PLoS computational biology · 2018Article
- Reduced Crossover Interference and Increased ZMM-Independent Recombination in the Absence of Tel1/ATM.PLoS genetics · 2015Article
- Recombination, Pairing, and Synapsis of Homologs during Meiosis.Cold Spring Harbor perspectives in biology · 2015Review
- Combined fluorescent and electron microscopic imaging unveils the specific properties of two classes of meiotic crossovers.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Hot regions of noninterfering crossovers coexist with a nonuniformly interfering pathway in Arabidopsis thaliana.Genetics · 2013Article
- Genome-wide crossover distribution in Arabidopsis thaliana meiosis reveals sex-specific patterns along chromosomes.PLoS genetics · 2011Article
- Article
- On the origin of crossover interference: A chromosome oscillatory movement (COM) model.Molecular cytogenetics · 2011Article
- Article
- Two types of meiotic crossovers coexist in maize.The Plant cell · 2009Article
- General pattern of meiotic recombination in male dogs estimated by MLH1 and RAD51 immunolocalization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed along the chromosome, and starting from its position, subsequent crossovers are placed with forward and backward stationary renewal processes using a chi-square distribution of intercrossover distances. We used our model as well as the standard chi-square model to simulate the patterns of crossover densities along bivalents or chromatids for those having zero, one, two, or three or more crossovers; indeed, such patterns depend on the number of crossovers. With both models, simulated patterns compare very well to those found experimentally in mice, both for MLH1 foci on bivalents and for crossovers on genetic maps. However, our model provides a better fit to experimental data as compared to the standard chi-square model, particularly regarding the distribution of numbers of crossovers per chromosome. Finally, our model predicts an enhancement of the recombination rate near the extremities, which, however, explains only a part of the pattern observed in mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.