ArticleGenetics2007
An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- The use of weighted multiple linear regression to estimate QTL × QTL × QTL interaction effects of winter wheat (Triticum aestivum L.) doubled-haploid lines.Journal of applied genetics · 2023Article
- Bayesian mixed models for longitudinal genetic data: theory, concepts, and simulation studies.Genomics & informatics · 2022Article
- Discovery of the Genomic Region and Candidate Genes of theFrontiers in plant science · 2020Article
- QTL Mapping on a Background of Variance Heterogeneity.G3 (Bethesda, Md.) · 2018Article
- Bayesian Analysis for Genetic Architectures of Body Weights and Morphological Traits Using Distorted Markers in Japanese Flounder Paralichthys olivaceus.Marine biotechnology (New York, N.Y.) · 2015Article
- Genome-wide QTL mapping of saltwater tolerance in sibling species of Anopheles (malaria vector) mosquitoes.Heredity · 2015Article
- Mapping complex traits as a dynamic system.Physics of life reviews · 2015Review
- Parametric and nonparametric statistical methods for genomic selection of traits with additive and epistatic genetic architectures.G3 (Bethesda, Md.) · 2014Article
- Two-stage genome-wide search for epistasis with implementation to Recombinant Inbred Lines (RIL) populations.PloS one · 2014Article
- Mixed-effects models for GAW18 longitudinal blood pressure data.BMC proceedings · 2014Article
- Impact of prior specifications in a shrinkage-inducing Bayesian model for quantitative trait mapping and genomic prediction.Genetics, selection, evolution : GSE · 2013Article
- Empirical Bayesian LASSO-logistic regression for multiple binary trait locus mapping.BMC genetics · 2013Article
- A decision rule for quantitative trait locus detection under the extended Bayesian LASSO model.Genetics · 2012Article
- Swift block-updating EM and pseudo-EM procedures for Bayesian shrinkage analysis of quantitative trait loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Multiple trait multiple interval mapping of quantitative trait loci from inbred line crosses.BMC genetics · 2012Article
- Simultaneous estimation of multiple quantitative trait loci and growth curve parameters through hierarchical Bayesian modeling.Heredity · 2012Article
- Bayesian variable selection in searching for additive and dominant effects in genome-wide data.PloS one · 2012Article
- Article
- Marker-assisted prediction of non-additive genetic values.Genetica · 2011Article
- A new mapping method for quantitative trait loci of silkworm.BMC genetics · 2011Article
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Authors and funding
6 authors.
Funding
Abstract
We extend our Bayesian model selection framework for mapping epistatic QTL in experimental crosses to include environmental effects and gene-environment interactions. We propose a new, fast Markov chain Monte Carlo algorithm to explore the posterior distribution of unknowns. In addition, we take advantage of any prior knowledge about genetic architecture to increase posterior probability on more probable models. These enhancements have significant computational advantages in models with many effects. We illustrate the proposed method by detecting new epistatic and gene-sex interactions for obesity-related traits in two real data sets of mice. Our method has been implemented in the freely available package R/qtlbim (http://www.qtlbim.org) to facilitate the general usage of the Bayesian methodology for genomewide interacting QTL analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.