ArticleGenetics2007
Centimorgan-range one-step mapping of fertility traits using interspecific recombinant congenic mice.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Deficiency in homozygous haplotypes reveals recessive lethal variants affecting fertility and viability in the Friesian horse.BMC genomics · 2026Article
- Article
- Towards a Multi-Omics of Male Infertility.The world journal of men's health · 2023Review
- Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Effects of quantitative trait loci determining testicular weight in DDD/Sgn inbred mice are strongly influenced by circulating testosterone levels.Asian-Australasian journal of animal sciences · 2019Article
- The multisystemic functions of FOXD1 in development and disease.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Genome-wide association for testis weight in the diversity outbred mouse population.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Male Infertility Is Responsible for Nearly Half of the Extinction Observed in the Mouse Collaborative Cross.Genetics · 2017Article
- Article
- Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans.Open biology · 2016Article
- Effect of the Y chromosome on testis weight in mice.The Journal of veterinary medical science · 2015Article
- Article
- Genome-wide association study identifies phospholipase C zeta 1 (PLCz1) as a stallion fertility locus in Hanoverian warmblood horses.PloS one · 2014Article
- Exploration of the genetic organization of morphological modularity on the mouse mandible using a set of interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species.G3 (Bethesda, Md.) · 2012Article
- QTL on mouse chromosomes 1 and 4 causing sperm-head morphological abnormality and male subfertility.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Nasal bone shape is under complex epistatic genetic control in mouse interspecific recombinant congenic strains.PloS one · 2012Article
- Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice.PloS one · 2011Article
- Evolution of sex-specific wing shape at the widerwing locus in four species of Nasonia.Heredity · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, male fertility is a quantitative feature determined by numerous genes. Until now, several wide chromosomal regions involved in fertility have been defined by genetic mapping approaches; unfortunately, the underlying genes are very difficult to identify. Here, 53 interspecific recombinant congenic mouse strains (IRCSs) bearing 1-2% SEG/Pas (Mus spretus) genomic fragments disseminated in a C57Bl/6J (Mus domesticus) background were used to systematically analyze male fertility parameters. One of the most prominent advantages of this model is the possibility of analyzing stable phenotypes in living animals. Here, we demonstrate the possibility in one-step fine mapping for several fertility traits. Focusing on strains harboring a unique spretus fragment, we could unambiguously localize two testis and one prostate weight-regulating QTL (Ltw1, Ltw2, and Lpw1), four QTL controlling the sperm nucleus shape (Sh1, Sh2, Sh3, and Sh4), and one QTL influencing sperm survival (Dss1). In several cases, the spretus DNA fragment was small enough to propose sound candidates. For instance, Spata1, Capza, and Tuba7 are very strong candidates for influencing the shape of the sperm head. Identifying new genes implied in mammalian fertility pathways is a necessary prerequisite for clarifying their molecular grounds and for proposing diagnostic tools for masculine infertilities.
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