ArticleEukaryotic cell2007
Protein arginine methylation in Candida albicans: role in nuclear transport.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- The MethyltransferaseJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Epigenetic regulation of pathogenicity in fungi.Current genetics · 2025Review
- Multi-Omics Profiling ofMicroorganisms · 2023Article
- Arginine methyltransferases PRMT2 and PRMT3 are essential for biosynthesis of plant-polysaccharide-degrading enzymes in Penicillium oxalicum.PLoS genetics · 2023Article
- Genome-Wide Identification of Maize Protein Arginine Methyltransferase Genes and Functional Analysis ofInternational journal of molecular sciences · 2022Article
- Protein arginine methyltransferases in protozoan parasites.Parasitology · 2022Review
- Cellular consequences of arginine methylation.Cellular and molecular life sciences : CMLS · 2019Review
- Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans.Fungal genetics and biology : FG & B · 2019Article
- TheFrontiers in cellular and infection microbiology · 2018Article
- Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1.Molecular microbiology · 2017Article
- Comparative Monomethylarginine Proteomics Suggests that Protein Arginine Methyltransferase 1 (PRMT1) is a Significant Contributor to Arginine Monomethylation inMolecular & cellular proteomics : MCP · 2017Article
- SR-like RNA-binding protein Slr1 affects Candida albicans filamentation and virulence.Infection and immunity · 2013Article
- Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.PloS one · 2013Article
- Posttranslational modifications of proteins in the pathobiology of medically relevant fungi.Eukaryotic cell · 2012Review
- The AMT1 arginine methyltransferase gene is important for plant infection and normal hyphal growth in Fusarium graminearum.PloS one · 2012Article
- Arginine methylation of the nuclear poly(a) binding protein weakens the interaction with its nuclear import receptor, transportin.The Journal of biological chemistry · 2011Article
- Protein arginine methylation in parasitic protozoa.Eukaryotic cell · 2011Review
- Characterization of the PRMT gene family in rice reveals conservation of arginine methylation.PloS one · 2011Article
- TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei.Eukaryotic cell · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Protein arginine methylation plays a key role in numerous eukaryotic processes, such as protein transport and signal transduction. In Candida albicans, two candidate protein arginine methyltransferases (PRMTs) have been identified from the genome sequencing project. Based on sequence comparison, C. albicans candidate PRMTs display similarity to Saccharomyces cerevisiae Hmt1 and Rmt2. Here we demonstrate functional homology of Hmt1 between C. albicans and S. cerevisiae: CaHmt1 supports growth of S. cerevisiae strains that require Hmt1, and CaHmt1 methylates Npl3, a major Hmt1 substrate, in S. cerevisiae. In C. albicans strains lacking CaHmt1, asymmetric dimethylarginine and omega-monomethylarginine levels are significantly decreased, indicating that Hmt1 is the major C. albicans type I PRMT1. Given the known effects of type I PRMTs on nuclear transport of RNA-binding proteins, we tested whether Hmt1 affects nuclear transport of a putative Npl3 ortholog in C. albicans. CaNpl3 allows partial growth of S. cerevisiae npl3Delta strains, but its arginine-glycine-rich C terminus can fully substitute for that of ScNpl3 and also directs methylation-sensitive association with ScNpl3. Expression of green fluorescent protein-tagged CaNpl3 proteins in C. albicans strains with and without CaHmt1 provides evidence for CaHmt1 facilitating export of CaNpl3 in this fungus. We have also identified the C. albicans Rmt2, a type IV fungus- and plant-specific PRMT, by amino acid analysis of an rmt2Delta/rmt2Delta strain, as well as biochemical evidence for additional cryptic PRMTs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.