ArticleBiophysical journal2007
A kinetic model for calcium dynamics in RAW 264.7 cells: 2. Knockdown response and long-term response.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Modeling transcriptional regulation of the cell cycle using a novel cybernetic-inspired approach.Biophysical journal · 2024Article
- Modeling of Endothelial Calcium Responses within a Microfluidic Generator of Spatio-Temporal ATP and Shear Stress Signals.Micromachines · 2021Article
- GPCR mediated control of calcium dynamics: A systems perspective.Cellular signalling · 2020Review
- Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism.PloS one · 2016Article
- Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Functional classification of skeletal muscle networks. I. Normal physiology.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Stochastic hybrid modeling of intracellular calcium dynamics.The Journal of chemical physics · 2010Article
- A dual receptor crosstalk model of G-protein-coupled signal transduction.PLoS computational biology · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
This article addresses how quantitative models such as the one proposed in the companion article can be used to study cellular network perturbations such as knockdowns and pharmacological perturbations in a predictive manner. Using the kinetic model for cytosolic calcium dynamics in RAW 264.7 cells developed in the companion article, the calcium response to complement 5a (C5a) for the knockdown of seven proteins (C5a receptor; G-beta-2; G-alpha,i-2,3; regulator of G-protein signaling-10; G-protein coupled receptor kinase-2; phospholipase C beta-3; arrestin) is predicted and validated against the data from the Alliance for Cellular Signaling. The knockdown responses provide insights into how altered expressions of important proteins in disease states result in intermediate measurable phenotypes. Long-term response and long-term dose response have also been predicted, providing insights into how the receptor desensitization, internalization, and recycle result in tolerance. Sensitivity analysis of long-term response shows that the mechanisms and parameters in the receptor recycle path are important for long-term calcium dynamics.
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