ArticleBiophysical journal2007
Effects of chlorpromazine and trinitrophenol on the membrane motor of outer hair cells.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- MSC EVs Deliver miRNAs into Cardiomyocytes via EIPA-Sensitive and Clathrin-Mediated Endocytosis.Biomedicines · 2026Article
- Diflunisal inhibits prestin by chloride-dependent mechanism.PloS one · 2017Article
- The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain.The Journal of biological chemistry · 2016Article
- The lipid composition and physical properties of the yeast vacuole affect the hemifusion-fusion transition.Traffic (Copenhagen, Denmark) · 2013Article
- Membrane cholesterol strongly influences confined diffusion of prestin.Biophysical journal · 2012Article
- Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density.PloS one · 2012Article
- Sensitivity of prestin-based membrane motor to membrane thickness.Biophysical journal · 2010Article
- Lipid lateral mobility in cochlear outer hair cells: regional differences and regulation by cholesterol.Journal of the Association for Research in Otolaryngology : JARO · 2009Article
- Amphipath-induced nanoscale changes in outer hair cell plasma membrane curvature.Biophysical journal · 2009Article
- Anion control of voltage sensing by the motor protein prestin in outer hair cells.Biophysical journal · 2008Article
- Probing conformational changes of prestin with thiol-reactive optical switches.Biophysical journal · 2008Article
- Cochlear amplification, outer hair cells and prestin.Current opinion in neurobiology · 2008Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The motile activity of outer hair cells' cell body is associated with large nonlinear capacitance due to a membrane motor that couples electric displacement with changes in the membrane area, analogous to piezoelectricity. This motor is based on prestin, a member of the SLC26 family of anion transporters and utilizes the electric energy available at the plasma membrane associated with the sensory function of these cells. To understand detailed mechanism of this motile activity, we examined the effect of amphipathic ions, cationic chlorpromazine and anionic trinitrophenol, which are thought to change the curvature of the membrane in opposite directions. We found that both chemicals reduced cell length at the holding potential of -75 mV and induced positive shifts in the cells' voltage dependence. The shift observed was approximately 10 mV for 500 microM trinitrophenol and 20 mV for 100 microM cationic chlorpromazine. Length reduction at the holding potential and voltage shifts of the motile activity were well correlated. The voltage shifts of nonlinear capacitance were not diminished by eliminating the cells' turgor pressure or by digesting the cortical cytoskeleton. These observations suggest that the membrane motor undergoes conformational transitions that involve changes not only in membrane area but also in bending stiffness.
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