Evidence map›Paper›PMID 17483164›Full record

ArticleBiophysical journal2007

Effect of ions on the organization of phosphatidylcholine/phosphatidic acid bilayers.

Lee R Cambrea, Farzin Haque, Jeremy L Schieler, Jean-Christophe Rochet, Jennifer S Hovis

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Liposomes Loaded with Unsaponifiable Matter fromNanomaterials (Basel, Switzerland) · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Gramicidin pores report the activity of membrane-active enzymes.Journal of the American Chemical Society · 2009
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lee R CambreaDepartment of Chemistry and Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.
Farzin Haque
Jeremy L Schieler
Jean-Christophe Rochet
Jennifer S Hovis
Purdue University West Lafayette · US

Funding

Membrane binding and aggregation of alpha-synucleinR01NS049221 · NINDS · PURDUE UNIVERSITY · PI ROCHET, JEAN-CHRISTOPHE · 2006 to 2009
$960k
NINDS NIH HHS R01 NS049221
6 · The paper itself

Abstract

Lipid bilayers are two-dimensional fluids. Here, the effect of monovalent ion concentration on the mixing, and consequently the organization, of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) bilayers has been examined. Epifluorescence microscopy was used to visualize the organization. Fluorescence recovery after photobleaching and attenuated total reflection-Fourier transform infrared spectroscopy were used to assess the fluidity of the lipids. At high ionic strength the DOPC and DOPA lipids appear uniformly mixed. Upon lowering the ionic strength, rapid separation is observed. The DOPA-rich regions appear fractal-like and exhibit hysteresis in their properties. The lipids freely exchange between the two regions. These experiments clearly demonstrate the significant effect that electrostatics can have on membrane organization.

Indexed as

Ionsalpha-SynucleinDihydroxyphenylalanineEscherichia coliFluorescence Recovery After PhotobleachingLipid BilayersLipidsMicroscopy, FluorescencePhosphatidic AcidsPhosphatidylcholinesProtein Structure, TertiarySpectroscopy, Fourier Transform InfraredStatic ElectricityTime Factors1,2-oleoylphosphatidylcholinealpha-SynucleinDihydroxyphenylalanineIonsLipid BilayersLipidsPhosphatidic AcidsPhosphatidylcholines

Identifiers

PMID17483164
PMCPMC1948047
OpenAlexW2021548296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.