ArticleBiomaterials2007
The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes.
Article in Biomaterials, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Streamlining recombinant peptide and protein production using a pre-configured elastin-like polypeptide expression cassette.PloS one · 2026Article
- Design and evaluation of ionically crosslinked multifunctional ELP-SA composite hydrogels for 3D cell culture.Regenerative biomaterials · 2025Article
- Purification of a Hydrophobic Elastin-Like Protein Toward Scale-Suitable Production of Biomaterials.Frontiers in bioengineering and biotechnology · 2022Article
- The State of the Art and Prospects for Osteoimmunomodulatory Biomaterials.Materials (Basel, Switzerland) · 2021Review
- Dexamethasone-Enhanced Microdialysis and Penetration Injury.Frontiers in bioengineering and biotechnology · 2020Review
- Protein based therapeutic delivery agents: Contemporary developments and challenges.Biomaterials · 2017Review
- Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy.Biomaterials · 2017Article
- Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.PloS one · 2016Article
- Applications of elastin-like polypeptides in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- Materials that harness and modulate the immune system.MRS bulletin · 2014Article
- IL-1Ra and its delivery strategies: inserting the association in perspective.Pharmaceutical research · 2013Review
- Sustained delivery of IL-1Ra from pluronic F127-based thermosensitive gel prolongs its therapeutic potentials.Pharmaceutical research · 2012Article
- Short-term and long-term effects of orthopedic biodegradable implants.Journal of long-term effects of medical implants · 2011Article
- Cell-cell signaling in co-cultures of macrophages and fibroblasts.Biomaterials · 2010Article
- Elastomeric polypeptide-based biomaterials.Journal of polymer science. Part A, Polymer chemistry · 2010Article
- Chronic inflammatory responses to microgel-based implant coatings.Journal of biomedical materials research. Part A · 2010Article
- Fusion order controls expression level and activity of elastin-like polypeptide fusion proteins.Protein science : a publication of the Protein Society · 2009Article
- Biomimetic strategies based on viruses and bacteria for the development of immune evasive biomaterials.Biomaterials · 2009Review
- Cytokine profiling using monocytes/macrophages cultured on common biomaterials with a range of surface chemistries.Journal of biomedical materials research. Part A · 2009Article
- In vivo cytokine-associated responses to biomaterials.Biomaterials · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this research was to investigate whether immobilized anti-inflammatory cytokines will signal changes in the inflammatory profile of cultured monocytes. A fusion protein of recombinant human IL-1 receptor antagonist and elastin-like peptide (IL-1ra-ELP) was expressed in Escherichia coli. THP-1 human monocytes were cultured on either carboxyl-terminated self-assembled monolayers (SAMs), or SAMs with either covalently immobilized or soluble IL-1ra-ELP. LPS-stimulated monocytes exposed to either soluble or immobilized IL-1ra-ELP were prevented from cell differentiation, showed attenuated expression of pro-inflammatory cytokines, and had increased production of anti-inflammatory and pro-wound healing cytokines. These results suggest that immobilized anti-inflammatory cytokines have the potential to be immunomodulatory biomaterials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.